Alpinia zerumbet and Its Potential Use as an Herbal Medication for Atherosclerosis: Mechanistic Insights from Cell and Rodent Studies.
3T3-L1 Cells
Alpinia
/ chemistry
Animals
Anti-Obesity Agents
/ pharmacology
Antioxidants
/ pharmacology
Atherosclerosis
/ drug therapy
Blood Glucose
/ chemistry
Humans
Hyperlipidemias
/ drug therapy
Inhibitory Concentration 50
Kinetics
Male
Medicine, Chinese Traditional
Mesocricetus
Mice
Nitric Oxide Synthase
Oils, Volatile
/ chemistry
Oxidative Stress
/ drug effects
Plant Extracts
/ pharmacology
Plant Preparations
/ therapeutic use
Rats
Risk Factors
Alpinia zerumbet
Atherosclerosis
Phytochemicals
Preventive effects
Journal
Lifestyle genomics
ISSN: 2504-3188
Titre abrégé: Lifestyle Genom
Pays: Switzerland
ID NLM: 101716139
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
10
2019
accepted:
19
05
2020
pubmed:
4
9
2020
medline:
3
8
2021
entrez:
4
9
2020
Statut:
ppublish
Résumé
Alpinia zerumbet (Pers.) Burtt. et Smith has been used as a flavor additive in food and a traditional medicine for centuries, especially in Guizhou Province, China, and it prolongs people's lives with multiple beneficial effects. Thus, one of the aims of this review was to expound the chemical constituents of this plant, especially its fruits. Since cardiovascular diseases, including atherosclerosis, pose a health threat to humans, another aim was to expound the possible mechanisms of its potential use as an herbal medication for atherosclerosis. In this study, 10 reports are cited to expound the potential bioactive compounds. Moreover, 33 reports explain the antihypertensive and antiatherosclerotic effects of the plant by ameliorating inflammation and endothelial dysfunction, increasing vasodilation, improving hyperlipidemia, downgrading the glucose status, and working as an antioxidant. A. zerumbetis rich in terpenes, essential oils, flavonoids, polyphenolics, and sterols. Pharmacological experiments showed that A. zerumbet has antioxidative and anti-inflammatory effects on the NF-κB signaling pathway and can ameliorate oxidative stress in the NOS-NO signaling pathway. Moreover, A. zerumbet demonstrates antihypertensive effects by accelerating vasorelaxant response and increasing 3T3-L1 intracellular cAMP, which has promising antiobesity properties, as well as hypolipidemic and anti-diabetic complication effects. A. zerumbet has potential functions and applications in the prevention of atherosclerosis, but further studies are required before clinical trials.
Sections du résumé
BACKGROUND/AIMS
Alpinia zerumbet (Pers.) Burtt. et Smith has been used as a flavor additive in food and a traditional medicine for centuries, especially in Guizhou Province, China, and it prolongs people's lives with multiple beneficial effects. Thus, one of the aims of this review was to expound the chemical constituents of this plant, especially its fruits. Since cardiovascular diseases, including atherosclerosis, pose a health threat to humans, another aim was to expound the possible mechanisms of its potential use as an herbal medication for atherosclerosis.
METHODS
In this study, 10 reports are cited to expound the potential bioactive compounds. Moreover, 33 reports explain the antihypertensive and antiatherosclerotic effects of the plant by ameliorating inflammation and endothelial dysfunction, increasing vasodilation, improving hyperlipidemia, downgrading the glucose status, and working as an antioxidant.
RESULTS
A. zerumbetis rich in terpenes, essential oils, flavonoids, polyphenolics, and sterols. Pharmacological experiments showed that A. zerumbet has antioxidative and anti-inflammatory effects on the NF-κB signaling pathway and can ameliorate oxidative stress in the NOS-NO signaling pathway. Moreover, A. zerumbet demonstrates antihypertensive effects by accelerating vasorelaxant response and increasing 3T3-L1 intracellular cAMP, which has promising antiobesity properties, as well as hypolipidemic and anti-diabetic complication effects.
CONCLUSIONS
A. zerumbet has potential functions and applications in the prevention of atherosclerosis, but further studies are required before clinical trials.
Identifiants
pubmed: 32882697
pii: 000508818
doi: 10.1159/000508818
doi:
Substances chimiques
Anti-Obesity Agents
0
Antioxidants
0
Blood Glucose
0
Oils, Volatile
0
Plant Extracts
0
Plant Preparations
0
Nitric Oxide Synthase
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
138-145Informations de copyright
© 2020 The Author(s) Published by S. Karger AG, Basel.