Coronavirus 2019, Microthromboses, and Platelet Activating Factor.
COVID-19
inflammation
mast cells
platelet-activating factor
thromboses
Journal
Clinical therapeutics
ISSN: 1879-114X
Titre abrégé: Clin Ther
Pays: United States
ID NLM: 7706726
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
04
08
2020
revised:
10
08
2020
accepted:
11
08
2020
pubmed:
5
9
2020
medline:
26
11
2020
entrez:
5
9
2020
Statut:
ppublish
Résumé
Recent articles have reported elevated markers of coagulation, endothelial injury, and microthromboses in lungs from deceased patients with coronavirus 2019 (COVID-19). Platelets are critical in the formation of thrombi, and their most potent trigger is platelet activating factor (PAF). PAF is produced by cells involved in host defense, and its biological actions bear similarities with COVID-19 disease manifestations, including pulmonary microthromboses and inflammation, possibly via activation of mast cells. The histamine
Identifiants
pubmed: 32883529
pii: S0149-2918(20)30357-X
doi: 10.1016/j.clinthera.2020.08.006
pmc: PMC7430296
pii:
doi:
Substances chimiques
Platelet Activating Factor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1850-1852Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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