TPO antibody positivity and adverse pregnancy outcomes.

Abortion, Spontaneous / etiology Autoantibodies / adverse effects Autoimmunity / physiology Female Humans Hypothyroidism / blood Pregnancy Pregnancy Complications / blood Pregnancy Outcome / epidemiology Thyroid Diseases / blood
levothyroxine miscarriage preterm birth thyroid autoimmunity thyroid peroxidase antibodies

Journal

Best practice & research. Clinical endocrinology & metabolism
ISSN: 1878-1594
Titre abrégé: Best Pract Res Clin Endocrinol Metab
Pays: Netherlands
ID NLM: 101120682

Informations de publication

Date de publication:
07 2020
Historique:
pubmed: 5 9 2020
medline: 15 12 2020
entrez: 5 9 2020
Statut: ppublish

Résumé

Thyroid autoimmunity (TAI) is prevalent amongst women of reproductive age. TAI describes the presence of circulating anti-thyroid autoantibodies that are targeted against the thyroid, with or without thyroid dysfunction. Thyroid peroxidase antibodies (TPOAb) are the most common anti-thyroid autoantibodies. Around 10% of biochemically euthyroid individuals also have an elevated TPOAb titre. Many studies have linked the presence of TPOAb to adverse maternal and fetal outcomes in pregnancy, in particular miscarriage and pre-term birth, even in the absence of thyroid dysfunction. The causal pathway is poorly understood and few trials have looked to find treatments to reduce adverse outcomes. This review discusses in detail the associated adverse outcomes of TPOAb in pregnancy and the results of trials exploring methods to reduce such outcomes. Recommendations for counselling and monitoring of women with TPOAb and suggested areas for future work are also outlined.

Identifiants

DOI: 10.1016/j.beem.2020.101433 PMID: 32883611
pubmed: 32883611
pii: S1521-690X(20)30060-9
doi: 10.1016/j.beem.2020.101433
pii:
doi:

Substances chimiques

Autoantibodies 0
thyroid microsomal antibodies 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101433

Subventions

Organisme : Medical Research Council
ID : MC_G1002674
Pays : United Kingdom

Informations de copyright

Crown Copyright © 2020. Published by Elsevier Ltd. All rights reserved.

Auteurs

R K Dhillon-Smith (RK)

Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Tommy's Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Centre for Women's and Newborn Health, Birmingham Women's and Children's Foundation Trust, Edgbaston, Birmingham, B15 2TG, UK. Electronic address: r.k.smith@bham.ac.uk.

A Coomarasamy (A)

Institute of Metabolism and Systems Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Tommy's Centre for Miscarriage Research, College of Medical & Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK; Centre for Women's and Newborn Health, Birmingham Women's and Children's Foundation Trust, Edgbaston, Birmingham, B15 2TG, UK.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Avortement spontané › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Maladies endocriniennes › Maladies de la thyroïde › Hypothyroïdie › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › TPO antibody positivity and adverse pregnancy outcomes.
questionsmedicales.fr › Maladies endocriniennes › Maladies de la thyroïde › TPO antibody positivity and adverse pregnancy outcomes.