pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology.
cancer physiology
cell adhesion molecules
ion channel
membrane potential
pH homeostasis
protonation
tumor immunity
tumor microenvironment
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
02 Sep 2020
02 Sep 2020
Historique:
received:
16
07
2020
revised:
25
08
2020
accepted:
26
08
2020
entrez:
5
9
2020
pubmed:
6
9
2020
medline:
6
9
2020
Statut:
epublish
Résumé
Tissue acidosis plays a pivotal role in tumor progression: in particular, interstitial acidosis promotes tumor cell invasion, and is a major contributor to the dysregulation of tumor immunity and tumor stromal cells. The cell membrane and integral membrane proteins commonly act as important sensors and transducers of altered pH. Cell adhesion molecules and cation channels are prominent membrane proteins, the majority of which is regulated by protons. The pathophysiological consequences of proton-sensitive ion channel function in cancer, however, are scarcely considered in the literature. Thus, the main focus of this review is to highlight possible events in tumor progression and tumor immunity where the pH sensitivity of cation channels could be of great importance.
Identifiants
pubmed: 32887220
pii: cancers12092484
doi: 10.3390/cancers12092484
pmc: PMC7565548
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHW 407/17-1
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHW 407/22-1
Organisme : Interdisziplinäres Zentrum für Klinische Forschung Münster
ID : Schw2/020/18
Organisme : European Marie Skłodowska-Curie Innovative Training Network
ID : 813834; H2020-MSCA-ITN-2018
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