Lactose-reduced infant formula with added corn syrup solids is associated with a distinct gut microbiota in Hispanic infants.
Hispanic
Infant
human milk
infant formula
sugar
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
entrez:
5
9
2020
pubmed:
6
9
2020
medline:
21
9
2021
Statut:
ppublish
Résumé
Infant formula feeding, compared with human milk, has been associated with development of a distinct infant gut microbiome, but no previous study has examined effects of formula with added sugars. This work examined differences in gut microbiota among 91 Hispanic infants who consumed human milk [at breast (BB) vs. pumped in bottle (BP)] and 2 kinds of infant formula [(traditional lactose-based (TF) vs. lactose-reduced with added sugar (ASF)]. At 1 and 6 months, infant stool was collected to characterize gut microbiota. At 6 months, mothers completed 24-hour dietary recalls and questionnaires to determine infant consumption of human milk (BB vs. BP) or formula (TF vs. ASF). Linear regression models were used to determine associations of milk consumption type and microbial features at 6 months. Infants in the formula groups exhibited a significantly more 'mature' microbiome than infants in the human milk groups with the most pronounced differences observed between the ASF vs. BB groups. In the ASF group, we observed reduced log-normalized abundance of
Identifiants
pubmed: 32887539
doi: 10.1080/19490976.2020.1813534
pmc: PMC7524300
doi:
Substances chimiques
High Fructose Corn Syrup
0
Lactose
J2B2A4N98G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1813534Subventions
Organisme : NICHD NIH HHS
ID : K99 HD098288
Pays : United States
Organisme : NIEHS NIH HHS
ID : R00 ES027853
Pays : United States
Organisme : NICHD NIH HHS
ID : R00 HD098288
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK110793
Pays : United States
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