Geometric pinning and antimixing in scaffolded lipid vesicles.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 09 2020
04 09 2020
Historique:
received:
18
02
2020
accepted:
01
07
2020
entrez:
5
9
2020
pubmed:
6
9
2020
medline:
30
9
2020
Statut:
epublish
Résumé
Previous studies on the phase behaviour of multicomponent lipid bilayers found an intricate interplay between membrane geometry and its composition, but a fundamental understanding of curvature-induced effects remains elusive. Thanks to a combination of experiments on lipid vesicles supported by colloidal scaffolds and theoretical work, we demonstrate that the local geometry and global chemical composition of the bilayer determine both the spatial arrangement and the amount of mixing of the lipids. In the mixed phase, a strong geometrical anisotropy can give rise to an antimixed state, where the lipids are mixed, but their relative concentration varies across the membrane. After phase separation, the bilayer organizes in multiple lipid domains, whose location is pinned in specific regions, depending on the substrate curvature and the bending rigidity of the lipid domains. Our results provide critical insights into the phase separation of cellular membranes and, more generally, two-dimensional fluids on curved substrates.
Identifiants
pubmed: 32887878
doi: 10.1038/s41467-020-17432-w
pii: 10.1038/s41467-020-17432-w
pmc: PMC7474073
doi:
Substances chimiques
Lipid Bilayers
0
Liposomes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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