Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade.

Autocrine Communication Chromosomes, Human, X Germ Layers Human Embryonic Stem Cells Humans X Chromosome Inactivation / genetics

Journal

Cell stem cell
ISSN: 1875-9777
Titre abrégé: Cell Stem Cell
Pays: United States
ID NLM: 101311472

Informations de publication

Date de publication:
03 09 2020
Historique:
entrez: 5 9 2020
pubmed: 6 9 2020
medline: 25 2 2021
Statut: ppublish

Résumé

In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

Identifiants

DOI: 10.1016/j.stem.2020.08.008 PMID: 32888422
pubmed: 32888422
pii: S1934-5909(20)30404-5
doi: 10.1016/j.stem.2020.08.008
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

352-353

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Emmanuel Cazottes (E)

Université de Paris, Epigenetics and Cell Fate, CNRS, F-75006 Paris, France.

Claire Rougeulle (C)

Université de Paris, Epigenetics and Cell Fate, CNRS, F-75006 Paris, France. Electronic address: claire.rougeulle@u-paris.fr.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Communication autocrine › Straight to the X: Modeling Human X Chromosome...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Chromosomes › Chromosomes sexuels › Chromosome X › Chromosomes X humains › Straight to the X: Modeling Human X Chromosome...
questionsmedicales.fr › Structures de l'embryon › Feuillets embryonnaires › Straight to the X: Modeling Human X Chromosome...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches embryonnaires › Cellules souches embryonnaires humaines › Straight to the X: Modeling Human X Chromosome...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Straight to the X: Modeling Human X Chromosome...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Compensation de dosage génétique › Inactivation du chromosome X › Straight to the X: Modeling Human X Chromosome...