Destructive and topical treatments of skin lesions in organ transplant recipients and relation to skin cancer.
Cryotherapy
Diathermy
Organ transplant recipients
Skin cancer
Topical treatment
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
13
06
2020
accepted:
26
08
2020
revised:
13
08
2020
pubmed:
6
9
2020
medline:
22
3
2022
entrez:
5
9
2020
Statut:
ppublish
Résumé
Various treatments of keratotic skin lesions and early skin cancers are performed in organ transplant recipients (OTRs) at high risk of skin malignancies but the frequency of their use is unknown. We prospectively assessed the frequency of use of cryotherapy, diathermy, and topical therapies and also investigated their associations with background incidence of histologically-confirmed squamous-cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of OTRs in Queensland, Australia. Median follow-up ranged from 1.7 to 3.2 years across organ transplant groups. Among 285 kidney, 125 lung and 203 liver transplant recipients [382 (62%) male, 380 (62%) immunosuppressed > 5 years, 394 (64%) previously diagnosed with skin cancer], 306 (50%) reported treatment of skin lesions with major types of non-excision therapies during follow-up: 278 (45%) cryotherapy or diathermy; 121 (20%) topical treatments. Of these 306, 150 (49%) developed SCC at double the incidence of those who did not receive these treatments, as assessed by incidence rate ratio (IRR) adjusted for age, sex, type of organ transplant, skin color and history of skin cancer at baseline, calculated by multivariable Poisson regression (IRR
Identifiants
pubmed: 32889576
doi: 10.1007/s00403-020-02136-4
pii: 10.1007/s00403-020-02136-4
pmc: PMC8850214
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
203-206Subventions
Organisme : National Health and Medical Research Council
ID : 552429
Informations de copyright
© 2020. The Author(s).
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