Study of lipoprotein(a) and its impact on atherosclerotic cardiovascular disease: Design and rationale of the Mass General Brigham Lp(a) Registry.
Atherosclerosis
/ blood
Biomarkers
/ blood
Biomedical Research
Cardiovascular Diseases
/ blood
Female
Follow-Up Studies
Humans
Hypolipidemic Agents
/ therapeutic use
Incidence
Lipoprotein(a)
/ blood
Male
Massachusetts
/ epidemiology
Middle Aged
Registries
Retrospective Studies
Risk Factors
Survival Rate
/ trends
ASCVD
lipoprotein(a)
natural language processing
prevention
Journal
Clinical cardiology
ISSN: 1932-8737
Titre abrégé: Clin Cardiol
Pays: United States
ID NLM: 7903272
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
10
06
2020
revised:
20
08
2020
accepted:
22
08
2020
pubmed:
8
9
2020
medline:
11
8
2021
entrez:
7
9
2020
Statut:
ppublish
Résumé
Lipoprotein(a) [Lp(a)] is independently associated with atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Elevated Lp(a) affects approximately one in five individuals and meaningfully contributes to the residual cardiovascular risk in individuals with otherwise well-controlled risk factors. With targeted therapies in the therapeutic pipeline, there is a need to further characterize the clinical phenotypes and outcomes of individuals with elevated levels of this unique biomarker. The Mass General Brigham Lp(a) Registry will be built from the longitudinal electronic health record of two large academic medical centers in Boston, Massachusetts, to develop a detailed cohort of patients who have had their Lp(a) measured. In combination with structured data sources, clinical documentation will be analyzed using natural language processing techniques to accurately characterize baseline characteristics. Important outcome measures including all-cause mortality, cardiovascular mortality, and cardiovascular events will be available for analysis. Approximately 30 000 patients who have had their Lp(a) tested within the Mass General Brigham system from January 2000 to July 2019 will be included in the registry. This large Lp(a) cohort will provide meaningful observational data regarding the differential risk associated with Lp(a) values and cardiovascular disease. With a new frontier of targeted Lp(a) therapies on the horizon, the Mass General Brigham Lp(a) Registry will help provide a deeper understanding of Lp(a)'s role in long term cardiovascular outcomes.
Identifiants
pubmed: 32893370
doi: 10.1002/clc.23456
pmc: PMC7661644
doi:
Substances chimiques
Biomarkers
0
Hypolipidemic Agents
0
Lipoprotein(a)
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1209-1215Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL094301
Pays : United States
Informations de copyright
© 2020 The Authors. Clinical Cardiology published by Wiley Periodicals LLC.
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