Short-Term Changes in Albuminuria and Risk of Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus: A Post Hoc Analysis of the EMPA-REG OUTCOME Trial.
Albuminuria
/ drug therapy
Benzhydryl Compounds
/ therapeutic use
Cardiovascular Diseases
/ etiology
Diabetes Mellitus, Type 2
/ complications
Double-Blind Method
Female
Glucosides
/ therapeutic use
Humans
Kidney Diseases
/ etiology
Male
Middle Aged
Risk Factors
Sodium-Glucose Transporter 2 Inhibitors
/ therapeutic use
Treatment Outcome
cardiovascular outcomes
empagliflozin
kidney (diabetes)
sodium‐glucose cotransporter 2 inhibitors
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
15 09 2020
15 09 2020
Historique:
pubmed:
8
9
2020
medline:
12
3
2021
entrez:
7
9
2020
Statut:
ppublish
Résumé
Background Early reduction in albuminuria with an SGLT2 (sodium-glucose cotransporter 2) inhibitor may be a positive indicator of long-term cardiovascular and renal benefits. We assessed changes in albuminuria during the first 12 weeks of treatment and subsequent long-term cardiovascular and renal risks associated with the SGLT2 inhibitor, empagliflozin, in the EMPA-REG OUTCOME (Empagliflozin Cardiovascular Outcome Event Trial in Type 2 diabetes Mellitus Patients) trial. Methods and Results We calculated the percentage urinary albumin creatinine ratio (UACR) change from baseline to week 12 in 6820 participants who did not experience a cardiovascular outcome (including 3-point major cardiovascular events and cardiovascular death or hospitalization for heart failure) or renal outcome (defined as 40% decline in estimated glomerular filtration rate from baseline, estimated glomerular filtration rate <15 mL/min per 1.73 m
Identifiants
pubmed: 32893717
doi: 10.1161/JAHA.120.016976
pmc: PMC7727012
doi:
Substances chimiques
Benzhydryl Compounds
0
Glucosides
0
Sodium-Glucose Transporter 2 Inhibitors
0
empagliflozin
HDC1R2M35U
Banques de données
ClinicalTrials.gov
['NCT01131676']
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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