The effects of chloride dynamics on substantia nigra pars reticulata responses to pallidal and striatal inputs.
Animals
Chlorides
/ metabolism
Computer Simulation
Corpus Striatum
/ physiology
Globus Pallidus
/ physiology
Mice
Neural Pathways
/ physiology
Neurons
/ metabolism
Optogenetics
/ methods
Pars Reticulata
/ physiology
Substantia Nigra
/ physiology
Synaptic Transmission
/ physiology
gamma-Aminobutyric Acid
/ metabolism
GABA
chloride homeostasis
decision-making
mouse
neuroscience
oscillations
substantia nigra
synchrony
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
07 09 2020
07 09 2020
Historique:
received:
29
01
2020
accepted:
14
08
2020
entrez:
7
9
2020
pubmed:
8
9
2020
medline:
17
2
2021
Statut:
epublish
Résumé
As a rodent basal ganglia (BG) output nucleus, the substantia nigra pars reticulata (SNr) is well positioned to impact behavior. SNr neurons receive GABAergic inputs from the striatum (direct pathway) and globus pallidus (GPe, indirect pathway). Dominant theories of action selection rely on these pathways' inhibitory actions. Yet, experimental results on SNr responses to these inputs are limited and include excitatory effects. Our study combines experimental and computational work to characterize, explain, and make predictions about these pathways. We observe diverse SNr responses to stimulation of SNr-projecting striatal and GPe neurons, including biphasic and excitatory effects, which our modeling shows can be explained by intracellular chloride processing. Our work predicts that ongoing GPe activity could tune the SNr operating mode, including its responses in decision-making scenarios, and GPe output may modulate synchrony and low-frequency oscillations of SNr neurons, which we confirm using optogenetic stimulation of GPe terminals within the SNr.
Identifiants
pubmed: 32894224
doi: 10.7554/eLife.55592
pii: 55592
pmc: PMC7476764
doi:
pii:
Substances chimiques
Chlorides
0
gamma-Aminobutyric Acid
56-12-2
Banques de données
Dryad
['10.5061/dryad.tb2rbnzwx']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01NS101016
Pays : United States
Organisme : National Science Foundation
ID : 1516288
Pays : International
Organisme : NIH HHS
ID : R01NS104835
Pays : United States
Organisme : NIH HHS
ID : R21NS095103
Pays : United States
Organisme : National Science Foundation
ID : 1612913
Pays : International
Organisme : National Science Foundation
ID : 1724240
Pays : International
Informations de copyright
© 2020, Phillips et al.
Déclaration de conflit d'intérêts
RP, IR, JR No competing interests declared, AG Reviewing editor, eLife
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