Comparative Analysis of Long Noncoding RNA Expression in Human Hepatocyte Cell Lines and Liver.

Carcinoma, Hepatocellular / genetics Cells, Cultured Hep G2 Cells Hepatocytes / cytology Humans Liver / cytology Liver Neoplasms / genetics RNA, Long Noncoding / biosynthesis RNA, Messenger / genetics
HepaRG liver cancer Кeywords: long noncoding RNAs

Journal

Doklady. Biochemistry and biophysics
ISSN: 1608-3091
Titre abrégé: Dokl Biochem Biophys
Pays: United States
ID NLM: 101126895

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 10 03 2020
accepted: 23 03 2020
revised: 23 03 2020
entrez: 7 9 2020
pubmed: 8 9 2020
medline: 20 2 2021
Statut: ppublish

Résumé

Long noncoding RNAs (lncRNAs) are promising biomarkers and potential targets for liver cancer therapy. Stable hepatocyte lines are used in vitro to investigate functions of lncRNAs which amount in cell fluctuates during carcinogenesis. For the first time we compared gene expression of known lncRNAs in human conditional normal liver cells HepaRG and cancer cell lines Huh7 and HepG2. We showed that relative amounts of these lncRNAs in HepaRG are close to analogous variables measured for liver samples from healthy donors. Obtained data demonstrate exclusive peculiarities of HepaRG and confirm its reasonable application as a model of normal human hepatocytes for studying functions of lncRNAs.

Identifiants

DOI: 10.1134/S1607672920040043 PMID: 32894460
pubmed: 32894460
doi: 10.1134/S1607672920040043
pii: 10.1134/S1607672920040043
doi:

Substances chimiques

RNA, Long Noncoding 0
RNA, Messenger 0

Types de publication

Comparative Study Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

181-184

Auteurs

O Y Burenina (OY)

Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia. alunit@inbox.ru.

T S Zatsepin (TS)

Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
Belozersky Institute of Physico-Chemical Biology and Chemistry Department, Moscow State University, Moscow, Russia.

E F Kim (EF)

Petrovsky National Research Centre of Surgery, Moscow, Russia.

A V Metelin (AV)

Petrovsky National Research Centre of Surgery, Moscow, Russia.

D A Skvortsov (DA)

Belozersky Institute of Physico-Chemical Biology and Chemistry Department, Moscow State University, Moscow, Russia.
Faculty of Biology and Biotechnologies, Higher School of Economics, Moscow, Russia.

M P Rubtsova (MP)

Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
Belozersky Institute of Physico-Chemical Biology and Chemistry Department, Moscow State University, Moscow, Russia.

O A Dontsova (OA)

Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
Belozersky Institute of Physico-Chemical Biology and Chemistry Department, Moscow State University, Moscow, Russia.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Carcinome hépatocellulaire › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Cellules › Cellules cultivées › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Cellules HepG2 › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Cellules › Cellules épithéliales › Hépatocytes › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Système digestif › Foie › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Tumeurs du foie › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Comparative Analysis of Long Noncoding RNA...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Comparative Analysis of Long Noncoding RNA...