KM-416, a novel phenoxyalkylaminoalkanol derivative with anticonvulsant properties exerts analgesic, local anesthetic, and antidepressant-like activities. Pharmacodynamic, pharmacokinetic, and forced degradation studies.
Analgesics
/ chemistry
Anesthetics, Local
/ chemistry
Animals
Anticonvulsants
/ chemistry
Antidepressive Agents
/ chemistry
Area Under Curve
Brain
/ metabolism
Capsaicin
/ pharmacology
Diabetic Neuropathies
/ drug therapy
Drug Stability
Epilepsy
Guinea Pigs
Hemodynamics
/ drug effects
Male
Mice
Neuralgia
/ drug therapy
Pain Measurement
Patch-Clamp Techniques
Rats
Rats, Wistar
Sodium Channel Blockers
/ pharmacology
Analgesic
Antidepressant-like activity
Forced degradation
Local anesthetic
Neuropathic pain
Pharmacokinetic studies
Journal
European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354
Informations de publication
Date de publication:
05 Nov 2020
05 Nov 2020
Historique:
received:
26
04
2020
revised:
01
09
2020
accepted:
03
09
2020
pubmed:
9
9
2020
medline:
15
5
2021
entrez:
8
9
2020
Statut:
ppublish
Résumé
Anticonvulsant drugs are used to treat a wide range of non-epileptic conditions, including chronic, neuropathic pain. We obtained a phenoxyalkylaminoalkanol derivative, KM-416 which had previously demonstrated a significant anticonvulsant activity and had also been shown to bind to 5-HT
Identifiants
pubmed: 32896552
pii: S0014-2999(20)30632-4
doi: 10.1016/j.ejphar.2020.173540
pii:
doi:
Substances chimiques
Analgesics
0
Anesthetics, Local
0
Anticonvulsants
0
Antidepressive Agents
0
Sodium Channel Blockers
0
Capsaicin
S07O44R1ZM
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173540Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.