Astrocyte Crosstalk in CNS Inflammation.

Animals Astrocytes / physiology Cell Communication / physiology Central Nervous System / physiopathology Humans Inflammation / physiopathology Models, Neurological
astrocyte cell interactions glial cells multiple sclerosis neuroinflammation trained immunity

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
25 11 2020
Historique:
received: 23 06 2020
revised: 12 08 2020
accepted: 14 08 2020
pubmed: 9 9 2020
medline: 23 1 2021
entrez: 8 9 2020
Statut: ppublish

Résumé

Astrocytes control multiple processes in the nervous system in health and disease. It is now clear that specific astrocyte subsets or activation states are associated with specific genomic programs and functions. The advent of novel genomic technologies has enabled rapid progress in the characterization of astrocyte heterogeneity and its control by astrocyte interactions with other cells in the central nervous system (CNS). In this review, we provide an overview of the multifaceted roles of astrocytes in the context of CNS inflammation, highlighting recent discoveries on astrocyte subsets and their regulation. We explore mechanisms of crosstalk between astrocytes and other cells in the CNS in the context of neuroinflammation and neurodegeneration and discuss how these interactions shape pathological outcomes.

Identifiants

DOI: 10.1016/j.neuron.2020.08.012 PMID: 32898475 PMC: PMC7704785
pubmed: 32898475
pii: S0896-6273(20)30643-7
doi: 10.1016/j.neuron.2020.08.012
pmc: PMC7704785
mid: NIHMS1622893
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

608-622

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS102807
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025530
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS114111
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI126880
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI093903
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES029136
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS101790
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA207021
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Mathias Linnerbauer (M)

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Michael A Wheeler (MA)

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Francisco J Quintana (FJ)

Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: fquintana@rics.bwh.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Astrocyte Crosstalk in CNS Inflammation.
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Astrocyte Crosstalk in CNS Inflammation.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Communication cellulaire › Astrocyte Crosstalk in CNS Inflammation.
questionsmedicales.fr › Système nerveux › Système nerveux central › Astrocyte Crosstalk in CNS Inflammation.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Astrocyte Crosstalk in CNS Inflammation.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Astrocyte Crosstalk in CNS Inflammation.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles neurologiques › Astrocyte Crosstalk in CNS Inflammation.