Preoperative carfilzomib and lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model.

Abatacept Animals Desensitization, Immunologic Graft Rejection / prevention & control Graft Survival Humans Immunosuppressive Agents Oligopeptides Primates
carfilzomib desensitization kidney transplant lulizumab sensitization

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
01 2021
Historique:
received: 25 05 2020
revised: 23 07 2020
accepted: 20 08 2020
pubmed: 9 9 2020
medline: 22 6 2021
entrez: 8 9 2020
Statut: ppublish

Résumé

Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the co-stimulatory signal (CD28-B7) with Lulizumab, which preserves the co-inhibitory signal (CTLA4-B7). Five maximally MHC-mismatched pairs of NHPs were sensitized to each other with two sequential skin transplants. Individuals from each pair were randomized to either desensitization with once-weekly Carfilzomib (27mg/m

Identifiants

DOI: 10.1016/j.kint.2020.08.020 PMID: 32898569 PMC: PMC7785689
pubmed: 32898569
pii: S0085-2538(20)31044-9
doi: 10.1016/j.kint.2020.08.020
pmc: PMC7785689
mid: NIHMS1631498
pii:
doi:

Substances chimiques

Immunosuppressive Agents 0
Oligopeptides 0
carfilzomib 72X6E3J5AR
Abatacept 7D0YB67S97

Types de publication

Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

161-172

Subventions

Organisme : NIAID NIH HHS
ID : U19 AI131471
Pays : United States

Informations de copyright

Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Paul M Schroder (PM)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Robin Schmitz (R)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Zachary W Fitch (ZW)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Brian Ezekian (B)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Janghoon Yoon (J)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Ashley Y Choi (AY)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Miriam Manook (M)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Andrew Barbas (A)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Frank Leopardi (F)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Mingqing Song (M)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Alton B Farris (AB)

Department of Pathology, Emory School of Medicine, Atlanta, Georgia, USA.

Bradley Collins (B)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.

Jean Kwun (J)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: jean.kwun@duke.edu.

Stuart J Knechtle (SJ)

Duke Transplant Center, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: stuart.knechtle@duke.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Abatacept › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Eucaryotes › Animaux › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Désensibilisation immunologique › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Rejet du greffon › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunologie en transplantation › Réaction de l'hôte contre le greffon › Survie du greffon › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Preoperative carfilzomib and lulizumab based...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Preoperative carfilzomib and lulizumab based...