Vitamin K and Kidney Transplantation.
Cardiovascular Diseases
/ etiology
Fractures, Bone
/ etiology
Humans
Kidney Transplantation
/ adverse effects
Neoplasms
/ etiology
Nutritional Status
Postoperative Complications
/ etiology
Preoperative Period
Renal Insufficiency, Chronic
/ blood
Treatment Outcome
Vitamin K 1
/ blood
Vitamin K 2
/ blood
Vitamin K Deficiency
/ complications
bone
calcification
cancer
cardiovascular disease
fracture
kidney
menaquinone
osteoporosis
phylloquinone
transplant
vitamin K
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
05 Sep 2020
05 Sep 2020
Historique:
received:
30
07
2020
revised:
28
08
2020
accepted:
01
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
27
3
2021
Statut:
epublish
Résumé
The assessment of the vitamin K status and its effects on clinical outcomes in kidney transplantation (KT) patients has sparked interest, but it is still largely unfulfilled. In part, this is due to difficulties in laboratory measurements of vitamin K, especially K2 vitamers. Vitamin K status is currently best assessed by measuring undercarboxylated vitamin-K-dependent proteins. The relative contribution of vitamin K1 and K2 to the health status of the general population and CKD (chronic kidney disease) patients, including KT patients, is also poorly studied. Through a complete and first review of the existing literature, we summarize the current knowledge of vitamin K pathophysiology and its potential role in preventing KT complications and improving organ survival. A specific focus is placed on cardiovascular complications, bone fractures, and the relationship between vitamin K and cancer. Vitamin K deficiency could determine adverse outcomes, and KT patients should be better studied for vitamin K assessment and modalities of effective therapeutic approaches.
Identifiants
pubmed: 32899501
pii: nu12092717
doi: 10.3390/nu12092717
pmc: PMC7551925
pii:
doi:
Substances chimiques
Vitamin K 2
11032-49-8
Vitamin K 1
84-80-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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