The Potential of Algal Biotechnology to Produce Antiviral Compounds and Biopharmaceuticals.
Antiviral Agents
/ chemistry
Betacoronavirus
/ drug effects
Biological Products
/ chemistry
COVID-19
COVID-19 Vaccines
Cell Nucleus
/ chemistry
Chlamydomonas reinhardtii
/ chemistry
Chloroplasts
/ chemistry
Coronavirus Infections
/ drug therapy
Genetic Engineering
/ methods
Humans
Lectins
/ chemistry
Middle East Respiratory Syndrome Coronavirus
/ drug effects
Pandemics
Pneumonia, Viral
/ drug therapy
Polyphenols
/ chemistry
Polysaccharides
/ chemistry
Severe acute respiratory syndrome-related coronavirus
/ drug effects
SARS-CoV-2
Severe Acute Respiratory Syndrome
/ drug therapy
Viral Vaccines
/ biosynthesis
COVID-19
Chlamydomonas reinhardtii
MERS-CoV
SARS-CoV-2
monoclonal antibody
recombinant antigen
transplastomic
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
04 Sep 2020
04 Sep 2020
Historique:
received:
17
08
2020
revised:
31
08
2020
accepted:
01
09
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
17
9
2020
Statut:
epublish
Résumé
The emergence of the Coronavirus Disease 2019 (COVID-19) caused by the SARS-CoV-2 virus has led to an unprecedented pandemic, which demands urgent development of antiviral drugs and antibodies; as well as prophylactic approaches, namely vaccines. Algae biotechnology has much to offer in this scenario given the diversity of such organisms, which are a valuable source of antiviral and anti-inflammatory compounds that can also be used to produce vaccines and antibodies. Antivirals with possible activity against SARS-CoV-2 are summarized, based on previously reported activity against Coronaviruses or other enveloped or respiratory viruses. Moreover, the potential of algae-derived anti-inflammatory compounds to treat severe cases of COVID-19 is contemplated. The scenario of producing biopharmaceuticals in recombinant algae is presented and the cases of algae-made vaccines targeting viral diseases is highlighted as valuable references for the development of anti-SARS-CoV-2 vaccines. Successful cases in the production of functional antibodies are described. Perspectives on how specific algae species and genetic engineering techniques can be applied for the production of anti-viral compounds antibodies and vaccines against SARS-CoV-2 are provided.
Identifiants
pubmed: 32899754
pii: molecules25184049
doi: 10.3390/molecules25184049
pmc: PMC7571207
pii:
doi:
Substances chimiques
Antiviral Agents
0
Biological Products
0
COVID-19 Vaccines
0
Lectins
0
Polyphenols
0
Polysaccharides
0
Viral Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Chulalongkorn University
ID : C2F
Organisme : undefined <span style="color:gray;font-size:10px;">undefined</span>
ID : CU_GI_62_08_33_01
Références
Mar Drugs. 2015 Jan 26;13(2):697-712
pubmed: 25629385
Antiviral Res. 2011 Nov;92(2):237-46
pubmed: 21867732
Emerg Microbes Infect. 2020 Dec;9(1):382-385
pubmed: 32065055
J Biotechnol. 2007 Jan 10;127(3):335-47
pubmed: 16959350
Plant Biotechnol J. 2010 Aug;8(6):719-33
pubmed: 20230484
Plant Biotechnol J. 2016 Jul;14(7):1541-50
pubmed: 26801740
Int J Biol Macromol. 2017 Sep;102:605-612
pubmed: 28431944
Antimicrob Agents Chemother. 2014;58(1):120-7
pubmed: 24145548
PLoS Genet. 2020 Jul 30;16(7):e1008944
pubmed: 32730252
Drug Discov Today. 2016 Feb;21(2):333-41
pubmed: 26546859
Bioresour Technol. 2013 Oct;145:345-50
pubmed: 23313179
J Ind Microbiol Biotechnol. 2011 Dec;38(12):1879-90
pubmed: 21882013
Bioresour Technol. 2019 Nov;292:121937
pubmed: 31408779
Clin Microbiol Rev. 2015 Apr;28(2):465-522
pubmed: 25810418
J Virol. 2010 Mar;84(5):2511-21
pubmed: 20032190
Plant Biotechnol J. 2011 Aug;9(6):674-83
pubmed: 21535358
Microb Cell Fact. 2018 Nov 24;17(1):186
pubmed: 30474564
Carbohydr Polym. 2015 Jan 22;115:122-8
pubmed: 25439876
Photosynth Res. 2015 Mar;123(3):227-39
pubmed: 24659086
Viruses. 2016 Nov 17;8(11):
pubmed: 27869695
Mar Drugs. 2012 Jul;10(7):1476-97
pubmed: 22851920
Int Immunopharmacol. 2008 Jan;8(1):109-16
pubmed: 18068106
Mar Drugs. 2015 May 15;13(5):2967-3028
pubmed: 25988519
Virol J. 2008 Sep 26;5:107
pubmed: 18817582
J Biotechnol. 2015 Dec 10;215:62-71
pubmed: 25975624
Antimicrob Agents Chemother. 2016 Oct 21;60(11):6518-6531
pubmed: 27550363
Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):E15-22
pubmed: 23236148
Antiviral Res. 2008 Nov;80(2):107-13
pubmed: 18584889
Biotechnol Adv. 2011 Nov-Dec;29(6):686-702
pubmed: 21664266
Bioimpacts. 2018;8(2):139-151
pubmed: 29977835
Phytomedicine. 2019 Aug;61:152809
pubmed: 31035050
J Nat Prod. 1996 Jan;59(1):83-7
pubmed: 8984158
J Biol Chem. 1993 Oct 15;268(29):21770-6
pubmed: 8408031
Biomed Res Int. 2015;2015:825203
pubmed: 26484353
Antimicrob Agents Chemother. 2003 Aug;47(8):2518-25
pubmed: 12878514
J Biol Chem. 2007 Apr 13;282(15):11021-9
pubmed: 17314091
Plant Biotechnol J. 2020 Feb 25;:
pubmed: 32096597
Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6099-104
pubmed: 19332801
Antiviral Res. 2003 Mar;58(1):47-56
pubmed: 12719006
Res Vet Sci. 2015 Feb;98:142-4
pubmed: 25435342
Viruses. 2016 Dec 17;8(12):
pubmed: 27999325
J Agric Food Chem. 2011 Jun 22;59(12):6467-73
pubmed: 21585204
Int J Biol Macromol. 2009 Apr 1;44(3):286-93
pubmed: 19263508
Bioorg Med Chem. 2013 Jul 1;21(13):3730-7
pubmed: 23647823
PLoS One. 2015 May 13;10(5):e0126577
pubmed: 25969984
PLoS One. 2018 Feb 6;13(2):e0192433
pubmed: 29408937
Viruses. 2016 Oct 24;8(10):
pubmed: 27783038
Biotechnol Appl Biochem. 2020 Jan;67(1):30-40
pubmed: 31538673
Biotechnol Lett. 2009 Jul;31(7):1043-9
pubmed: 19322523
Planta Med. 2007 Nov;73(14):1464-8
pubmed: 17948168
Protein Expr Purif. 2016 Jul;123:70-4
pubmed: 26851659
PLoS One. 2010 Dec 14;5(12):e14320
pubmed: 21179403
Food Chem Toxicol. 2016 Jan;87:31-44
pubmed: 26615870
Mar Drugs. 2015 Dec 29;14(1):4
pubmed: 26729137
Plant Cell. 2013 Aug;25(8):3089-103
pubmed: 23983220
Int J Antimicrob Agents. 2020 Mar;55(3):105924
pubmed: 32081636
Biomaterials. 2016 Jan;75:25-36
pubmed: 26474040
Viruses. 2018 Aug 30;10(9):
pubmed: 30200234
AIDS Res Hum Retroviruses. 1996 Oct 10;12(15):1463-71
pubmed: 8893054
Mar Drugs. 2011 Feb 08;9(2):196-223
pubmed: 21566795
Regul Toxicol Pharmacol. 2017 Jun;86:193-198
pubmed: 28284712
Bioresour Technol. 2019 Nov;291:121879
pubmed: 31377048
PLoS One. 2015 Jun 08;10(6):e0128794
pubmed: 26053018
Front Biosci (Schol Ed). 2018 Jan 1;10:197-216
pubmed: 28930527
Trends Immunol. 2020 May;41(5):355-359
pubmed: 32249063
Biomed Pharmacother. 2008 Jun;62(5):303-7
pubmed: 18455359
Biochem Biophys Res Commun. 2005 Jul 1;332(2):392-7
pubmed: 15896707
J Biochem Biophys Methods. 2002 Jan 4;50(2-3):189-200
pubmed: 11741707
Br J Nutr. 1998 Aug;80 Suppl 1:S77-112
pubmed: 9849355
Plant J. 2009 Apr;58(1):165-74
pubmed: 19054357
Microbes Infect. 2013 Apr;15(4):302-9
pubmed: 23376164
Mar Drugs. 2013 Jan 23;11(1):233-52
pubmed: 23344113
Plant Mol Biol. 2016 Mar;90(4-5):403-18
pubmed: 26747175
Biol Pharm Bull. 2012;35(7):1137-44
pubmed: 22791163
Antimicrob Agents Chemother. 1997 Jul;41(7):1521-30
pubmed: 9210678
Biotechnol Biofuels. 2019 Mar 25;12:66
pubmed: 30962821
Science. 1989 Oct 13;246(4927):227-34
pubmed: 2552581
Antioxidants (Basel). 2019 Jun 27;8(7):
pubmed: 31252612
Antiviral Res. 2016 Sep;133:1-8
pubmed: 27424494
Bioresour Technol. 2007 Jan;98(2):361-7
pubmed: 16473007
PLoS One. 2011;6(8):e22635
pubmed: 21829638
Nat Rev Drug Discov. 2020 May;19(5):305-306
pubmed: 32273591
Respir Res. 2013 Nov 13;14:124
pubmed: 24219370
Am J Transl Res. 2019 Mar 15;11(3):1884-1894
pubmed: 30972212
Toxicol In Vitro. 2009 Sep;23(6):1123-30
pubmed: 19490939
J Agric Food Chem. 2008 Dec 24;56(24):12073-80
pubmed: 19053379
Antimicrob Agents Chemother. 2020 May 21;64(6):
pubmed: 32229493
Nature. 2002 Jul 25;418(6896):430-4
pubmed: 12087357
Mar Drugs. 2011;9(5):819-31
pubmed: 21673891
Mar Drugs. 2014 Jun 10;12(6):3487-515
pubmed: 24918452
Acta Pharm Sin B. 2018 Mar;8(2):131-136
pubmed: 29719774
Int J Antimicrob Agents. 2018 Nov;52(5):599-607
pubmed: 30040991
Plant Biotechnol J. 2019 Nov;17(11):2032-2034
pubmed: 31131534
Appl Environ Microbiol. 2006 Dec;72(12):7477-84
pubmed: 17012596
PLoS One. 2013 Apr 23;8(4):e61473
pubmed: 23626690
Expert Opin Biol Ther. 2012 Jun;12(6):783-93
pubmed: 22506983
Mar Biotechnol (NY). 2004 Jan-Feb;6(1):17-25
pubmed: 14508657
Int J Biol Macromol. 2019 Jun 1;130:429-436
pubmed: 30797011
PLoS One. 2011;6(12):e28424
pubmed: 22164289
PLoS One. 2013 Apr 23;8(4):e61790
pubmed: 23626728
Mar Drugs. 2011;9(10):1806-28
pubmed: 22072997
J Biotechnol. 2018 Sep 20;282:86-91
pubmed: 30031093
J Gen Virol. 2011 Jun;92(Pt 6):1332-1342
pubmed: 21325483
Antiviral Res. 2012 Feb;93(2):253-259
pubmed: 22197247
Mar Drugs. 2017 Feb 21;15(2):
pubmed: 28230766
Mar Biotechnol (NY). 2008 May-Jun;10(3):219-26
pubmed: 18204953
Respir Res. 2010 Aug 10;11:108
pubmed: 20696083
Biotechnol Lett. 2010 Oct;32(10):1373-83
pubmed: 20556634
Plant Biotechnol J. 2016 Jun;14(6):1427-37
pubmed: 26800650
Int J Mol Sci. 2016 Jun 17;17(6):
pubmed: 27322258
Plant Biotechnol J. 2015 Jun;13(5):708-16
pubmed: 25470212
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Nucleic Acids Res. 2018 Jul 27;46(13):6909-6919
pubmed: 30053227
Prog Lipid Res. 2004 May;43(3):228-65
pubmed: 15003396
Nat Rev Microbiol. 2009 Jun;7(6):439-50
pubmed: 19430490
Front Pharmacol. 2019 Aug 28;10:906
pubmed: 31555126
Science. 2000 May 26;288(5470):1370-2
pubmed: 10847851
J Biol Chem. 2005 Dec 16;280(50):41278-88
pubmed: 16174777
Biol Pharm Bull. 2007 Aug;30(8):1573-5
pubmed: 17666824
Planta Med. 2005 Apr;71(4):379-81
pubmed: 15856421
Virology. 2012 Feb 20;423(2):175-86
pubmed: 22209231
Trends Biotechnol. 2008 Mar;26(3):126-31
pubmed: 18221809
Eur J Pharmacol. 2008 Sep 4;591(1-3):114-23
pubmed: 18625217
Lancet. 2020 Feb 15;395(10223):497-506
pubmed: 31986264
AIDS Res Hum Retroviruses. 2012 Feb;28(2):206-14
pubmed: 21793733
Adv Biosci Biotechnol. 2011 Dec;2(6):404-408
pubmed: 22611520
PLoS One. 2019 Jan 10;14(1):e0210009
pubmed: 30629622
Bioorg Med Chem. 2008 Sep 1;16(17):7921-6
pubmed: 18693022
Multidiscip Respir Med. 2014 Nov 12;9(1):57
pubmed: 25411637
PLoS One. 2010 Dec 16;5(12):e14360
pubmed: 21179548
Mini Rev Med Chem. 2017;17(13):1173-1193
pubmed: 27633748
Mar Drugs. 2013 Jul 16;11(7):2510-73
pubmed: 23880931
Sci Rep. 2017 Jan 17;7:40760
pubmed: 28094330
J Med Primatol. 2007 Aug;36(4-5):244-53
pubmed: 17669213
Biochemistry. 2003 Mar 11;42(9):2578-84
pubmed: 12614152
Arzneimittelforschung. 2000 Dec;50(12):1106-9
pubmed: 11190776
J Biol Chem. 2005 Mar 11;280(10):9345-53
pubmed: 15613479
Antiviral Res. 2005 Jan;65(1):45-8
pubmed: 15652970
Comp Biochem Physiol C Toxicol Pharmacol. 2007 Jul-Aug;146(1-2):60-78
pubmed: 16901759
Mar Biotechnol (NY). 2012 Aug;14(4):468-78
pubmed: 22193590
Cells. 2020 Mar 05;9(3):
pubmed: 32151094
Front Microbiol. 2017 Jun 30;8:1100
pubmed: 28713333
Int J Biol Macromol. 1997 Apr;20(2):97-105
pubmed: 9184941
Life Sci. 2014 Apr 17;101(1-2):56-63
pubmed: 24582595
ACS Synth Biol. 2018 Nov 16;7(11):2547-2557
pubmed: 30296377
Carbohydr Polym. 2015 Nov 20;133:213-20
pubmed: 26344274
BMC Complement Altern Med. 2012 Sep 05;12:147
pubmed: 22950667
Cancer Cell Int. 2002 Jul 5;2(1):8
pubmed: 12204093
Plant Cell Rep. 2016 May;35(5):1133-41
pubmed: 26886711
J Virol. 2001 Mar;75(5):2041-50
pubmed: 11160708
Front Microbiol. 2015 Dec 15;6:1376
pubmed: 26696985
Photosynth Res. 2007 May;92(2):245-59
pubmed: 17634749
Crit Rev Food Sci Nutr. 2016 Oct 2;56(13):2209-22
pubmed: 25674822
Mol Biotechnol. 2019 Feb;61(2):134-144
pubmed: 30543053
Plant Biotechnol J. 2017 Sep;15(9):1214-1224
pubmed: 28207991
Microb Cell Fact. 2012 Sep 13;11:126
pubmed: 22970838
Plant Biotechnol J. 2015 Jan;13(1):117-24
pubmed: 25229405
Photosynth Res. 2010 Nov;106(1-2):89-102
pubmed: 20734232
Biotechnol Bioeng. 2004 Mar 5;85(5):475-81
pubmed: 14760687
Mar Drugs. 2013 Aug 19;11(8):3000-14
pubmed: 23966033
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15214-9
pubmed: 25288733
J Appl Microbiol. 2016 Oct;121(4):919-31
pubmed: 27406848
Photosynth Res. 2015 Sep;125(3):423-36
pubmed: 25921207
Iran J Pharm Res. 2016 Summer;15(3):483-491
pubmed: 27980583
Expert Opin Biol Ther. 2020 Jul;20(7):751-766
pubmed: 32142617
PLoS One. 2014 Apr 07;9(4):e94028
pubmed: 24710110
Proteins. 2007 May 15;67(3):661-70
pubmed: 17340634
J Appl Phycol. 2018;30(3):1833-1858
pubmed: 32214665
Nutrients. 2019 May 29;11(6):
pubmed: 31146462
Protein Expr Purif. 2006 May;47(1):194-202
pubmed: 16300962
Microbiology (Reading). 2020 Jun;166(6):510-515
pubmed: 32250732
Nature. 2020 Jul;583(7816):459-468
pubmed: 32353859
Mol Pharm. 2012 Sep 4;9(9):2613-25
pubmed: 22827601
Antiviral Res. 1999 Nov;44(1):67-73
pubmed: 10588334
J Sci Food Agric. 2016 Apr;96(6):1856-66
pubmed: 26455344
Virology. 2010 Jun 20;402(1):187-96
pubmed: 20392471
Antioxidants (Basel). 2017 Oct 28;6(4):
pubmed: 29143759
Biomed Res Int. 2016;2016:8502123
pubmed: 27419139
Pharmaceutics. 2019 Apr 16;11(4):
pubmed: 30995761
Mar Drugs. 2019 Dec 20;18(1):
pubmed: 31861879