Impact of a Moderately Hypocaloric Mediterranean Diet on the Gut Microbiota Composition of Italian Obese Patients.
Adult
Caloric Restriction
/ methods
Diet, Mediterranean
Dysbiosis
/ diet therapy
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ physiology
Humans
Italy
Male
Middle Aged
Obesity
/ diet therapy
Overweight
/ diet therapy
Phylogeny
RNA, Bacterial
/ analysis
RNA, Ribosomal, 16S
Treatment Outcome
16S rRNA
Mediterranean diet
gut microbiota
high-throughput sequencing
obesity
weight loss
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
04 Sep 2020
04 Sep 2020
Historique:
received:
06
07
2020
revised:
21
08
2020
accepted:
31
08
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
27
3
2021
Statut:
epublish
Résumé
Although it is known that the gut microbiota (GM) can be modulated by diet, the efficacy of specific dietary interventions in determining its composition and diversity in obese patients remains to be ascertained. The present work aims to evaluate the impact of a moderately hypocaloric Mediterranean diet on the GM of obese and overweight patients (OB). The GM of 23 OB patients (F/M = 20/3) was compared before (T0) and after 3 months (T3) of nutritional intervention (NI). Fecal samples were analyzed by Illumina MiSeq sequencing of the 16S rRNA gene. At baseline, GM characterization confirmed typical obesity-associated dysbiosis. After 3 months of NI, patients presented a statistically significant reduction in body weight and fat mass, along with changes in the relative abundance of many microbial patterns. In fact, an increase in the abundance of several Bacteroidetes taxa (i.e., Sphingobacteriaceae,
Identifiants
pubmed: 32899756
pii: nu12092707
doi: 10.3390/nu12092707
pmc: PMC7551852
pii:
doi:
Substances chimiques
RNA, Bacterial
0
RNA, Ribosomal, 16S
0
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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