Design and Identification of a GPR40 Full Agonist (
Animals
Benzamides
/ chemical synthesis
CHO Cells
Cricetulus
Diabetes Mellitus, Experimental
/ drug therapy
Hypoglycemic Agents
/ chemical synthesis
Male
Mice, Inbred ICR
Molecular Structure
Piperidines
/ chemical synthesis
Rats, Sprague-Dawley
Receptors, G-Protein-Coupled
/ agonists
Structure-Activity Relationship
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
24 09 2020
24 09 2020
Historique:
pubmed:
10
9
2020
medline:
5
1
2021
entrez:
9
9
2020
Statut:
ppublish
Résumé
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 agonist is an attractive target for the treatment of type 2 diabetes mellitus. Using the reported biaryl derivative
Identifiants
pubmed: 32900194
doi: 10.1021/acs.jmedchem.0c00843
doi:
Substances chimiques
Benzamides
0
Ffar1 protein, mouse
0
G-protein-coupled receptor 40, rat
0
Hypoglycemic Agents
0
Piperidines
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM