Hemolymph protease-5 links the melanization and Toll immune pathways in the tobacco hornworm,

Animals Hemolymph / enzymology Insect Proteins / immunology Manduca / enzymology Serine Proteases / immunology Signal Transduction Toll-Like Receptors / immunology
clip domain hemolymph protein insect immunity serine protease cascade zymogen activation

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
22 09 2020
Historique:
pubmed: 10 9 2020
medline: 18 11 2020
entrez: 9 9 2020
Statut: ppublish

Résumé

Proteolytic activation of phenoloxidase (PO) and the cytokine Spätzle during immune responses of insects is mediated by a network of hemolymph serine proteases (HPs) and noncatalytic serine protease homologs (SPHs) and inhibited by serpins. However, integration and conservation of the system and its control mechanisms are not fully understood. Here we present biochemical evidence that PO-catalyzed melanin formation, Spätzle-triggered Toll activation, and induced synthesis of antimicrobial peptides are stimulated via hemolymph (serine) protease 5 (HP5) in

Identifiants

DOI: 10.1073/pnas.2004761117 PMID: 32900946 PMC: PMC7519321
pubmed: 32900946
pii: 2004761117
doi: 10.1073/pnas.2004761117
pmc: PMC7519321
doi:

Substances chimiques

Insect Proteins 0
Toll-Like Receptors 0
Serine Proteases EC 3.4.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

23581-23587

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM058634
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139998
Pays : United States
Organisme : NIGMS NIH HHS
ID : R37 GM041247
Pays : United States

Déclaration de conflit d'intérêts

The authors declare no competing interest.

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Auteurs

Yang Wang (Y)

Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078.
ORCID: 0000-0002-1202-9965

Fan Yang (F)

Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078.

Xiaolong Cao (X)

Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078.
ORCID: 0000-0001-8124-7491

Zhen Zou (Z)

Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078.

Zhiqiang Lu (Z)

Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078.

Michael R Kanost (MR)

Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506.

Haobo Jiang (H)

Department of Entomology and Plant Pathology, Oklahoma State University, Stillwater, OK 74078; haobo.jiang@okstate.edu.
ORCID: 0000-0003-1357-1315

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Hemolymph protease-5 links the melanization...
questionsmedicales.fr › Structures anatomiques de l'animal › Hémolymphe › Hemolymph protease-5 links the melanization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Hemolymph protease-5 links the melanization...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Lepidoptera › Papillons de nuit › Manduca › Hemolymph protease-5 links the melanization...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Hemolymph protease-5 links the melanization...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Hemolymph protease-5 links the melanization...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Hemolymph protease-5 links the melanization...