Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise.
AMP-Activated Protein Kinases
/ metabolism
Adaptation, Physiological
/ physiology
Adipocytes
/ metabolism
Adipose Tissue
/ metabolism
Animals
Cells, Cultured
DEAD-box RNA Helicases
/ deficiency
Exercise
/ physiology
Female
Glycolysis
Humans
Male
Mice
Mice, Knockout
MicroRNAs
/ genetics
Physical Conditioning, Animal
Ribonuclease III
/ deficiency
adipose tissue
cross-talk
exercise
metabolic flexibility
microRNA
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
22 09 2020
22 09 2020
Historique:
pubmed:
10
9
2020
medline:
20
11
2020
entrez:
9
9
2020
Statut:
ppublish
Résumé
DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body metabolic adaptations to aerobic exercise training, in part, by allowing controlled substrate utilization in adipose tissue, which, in turn, supports skeletal muscle function. Exercise training increases overall miRNA expression in adipose tissue, and up-regulation of miR-203-3p limits glycolysis in adipose under conditions of metabolic stress. We propose that exercise training-induced DICER-miR-203-3p up-regulation in adipocytes is a key adaptive response that coordinates signals from working muscle to promote whole-body metabolic adaptations.
Identifiants
pubmed: 32900951
pii: 2011243117
doi: 10.1073/pnas.2011243117
pmc: PMC7519274
doi:
Substances chimiques
MIRN203 microRNA, human
0
MIRN203 microRNA, mouse
0
MicroRNAs
0
AMP-Activated Protein Kinases
EC 2.7.11.31
DICER1 protein, human
EC 3.1.26.3
Dicer1 protein, mouse
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
DEAD-box RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23932-23941Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK082659
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Cell Rep. 2017 Feb 7;18(6):1558-1572
pubmed: 28178530
Nature. 2017 Feb 23;542(7642):450-455
pubmed: 28199304
J Appl Physiol (1985). 2010 Dec;109(6):1573-81
pubmed: 20651217
Acta Physiol (Oxf). 2018 Apr;222(4):e13009
pubmed: 29197155
Annu Rev Physiol. 1976;38:273-91
pubmed: 130825
Sci Rep. 2018 Jun 22;8(1):9562
pubmed: 29934543
Am J Physiol Endocrinol Metab. 2002 Jul;283(1):E58-65
pubmed: 12067843
Nat Commun. 2012 May 29;3:865
pubmed: 22643892
Nature. 2012 Jan 11;481(7382):463-8
pubmed: 22237023
Diabetes. 2013 Mar;62(3):864-74
pubmed: 23321074
Cell Metab. 2014 Dec 2;20(6):939-52
pubmed: 25448702
Cell Metab. 2017 May 2;25(5):1186-1193.e4
pubmed: 28467934
Nat Rev Endocrinol. 2016 Sep;12(9):504-17
pubmed: 27230949
Diabetes. 2000 May;49(5):677-83
pubmed: 10905472
Mol Cell Endocrinol. 2017 Jan 15;440:44-56
pubmed: 27840174
Diabetes. 2015 Jun;64(6):2002-14
pubmed: 25605808
Cell. 2014 Jun 5;157(6):1279-1291
pubmed: 24906147
Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E500-8
pubmed: 16188906
Cell. 2014 Sep 25;159(1):33-45
pubmed: 25259918
J Physiol. 2013 Oct 15;591(20):5207-20
pubmed: 23918774
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10746-51
pubmed: 19520829
Cancer Sci. 2005 Feb;96(2):111-5
pubmed: 15723655
Mol Metab. 2019 Nov;29:124-135
pubmed: 31668384
J Physiol. 2006 Dec 15;577(Pt 3):1021-32
pubmed: 17038425
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16092-7
pubmed: 21896769
Mol Cell Oncol. 2016 Feb 26;3(3):e1155006
pubmed: 27314098
Scand J Med Sci Sports. 2015 Feb;25(1):e59-69
pubmed: 24845952
Mol Metab. 2017 Oct;6(10):1313-1320
pubmed: 29031730
Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8
pubmed: 20616029
Nature. 2009 Apr 23;458(7241):1056-60
pubmed: 19262508
J Mol Endocrinol. 2014 Jun;52(3):R199-222
pubmed: 24577718
Cell Metab. 2014 Jan 7;19(1):96-108
pubmed: 24411942
J Clin Invest. 2006 Jul;116(7):1776-83
pubmed: 16823475
FEBS J. 2014 Oct;281(19):4421-38
pubmed: 25065674
PLoS One. 2015 Sep 21;10(9):e0138344
pubmed: 26390217
Nat Rev Endocrinol. 2019 Jul;15(7):383-392
pubmed: 30837717
Cancer Cell. 2012 Nov 13;22(5):585-600
pubmed: 23153533
Cell Metab. 2008 Jan;7(1):45-56
pubmed: 18177724
J Biol Chem. 2003 Aug 15;278(33):30413-6
pubmed: 12788931
Cell Signal. 2009 May;21(5):760-6
pubmed: 19167487
Prog Cardiovasc Dis. 1976 May-Jun;18(6):445-58
pubmed: 180563
J Biol Chem. 2006 Dec 29;281(52):40236-41
pubmed: 17074755
Diabetes. 2014 Dec;63(12):4045-56
pubmed: 25008181
Cell Metab. 2017 May 2;25(5):1027-1036
pubmed: 28467922
Am J Physiol Endocrinol Metab. 2015 May 15;308(10):E879-90
pubmed: 25783895
Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E505-13
pubmed: 19491295
Sci Rep. 2017 Feb 20;7:42680
pubmed: 28218277
Nat Metab. 2019 Feb;1(2):291-303
pubmed: 31032475
J Clin Invest. 2014 Aug;124(8):3339-51
pubmed: 24983316
Cell Metab. 2015 Mar 3;21(3):468-78
pubmed: 25738461
Front Physiol. 2015 Mar 24;6:85
pubmed: 25852572
J Biol Chem. 2002 Sep 6;277(36):32571-7
pubmed: 12065578
J Biol Chem. 2008 Jun 13;283(24):16514-24
pubmed: 18390901
Cell Metab. 2018 Feb 6;27(2):378-392.e5
pubmed: 29414686
Adipocyte. 2016 Mar 10;5(2):212-23
pubmed: 27386161
Cell Metab. 2012 Sep 5;16(3):336-47
pubmed: 22958919
Acta Physiol Scand. 2003 Aug;178(4):435-42
pubmed: 12864749
Aging (Albany NY). 2016 Jun;8(6):1201-22
pubmed: 27241713
Clin Exp Pharmacol Physiol. 2020 Jan;47(1):85-94
pubmed: 31408201
EBioMedicine. 2020 Mar;53:102697
pubmed: 32143184
J Cancer Sci Ther. 2015;7(2):34-43
pubmed: 26819680
Aging (Albany NY). 2009 Aug 15;1(9):771-83
pubmed: 20157566
Cell. 2014 Nov 6;159(4):738-49
pubmed: 25417152
J Exp Biol. 2018 Mar 7;221(Pt Suppl 1):
pubmed: 29514893
J Physiol. 2013 Sep 15;591(18):4637-53
pubmed: 23798494
J Clin Invest. 1982 Apr;69(4):785-93
pubmed: 6804492
Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E578-91
pubmed: 19531645
Med Sci Sports Exerc. 2015 Nov;47(11):2329-39
pubmed: 25785931
Cold Spring Harb Perspect Med. 2018 Aug 1;8(8):
pubmed: 28507197
Aging Cell. 2016 Jun;15(3):572-81
pubmed: 26990999
Am J Physiol. 1990 Feb;258(2 Pt 1):E382-9
pubmed: 2106269
Physiol Rev. 2006 Jan;86(1):205-43
pubmed: 16371598
Mol Metab. 2019 Oct;28:36-47
pubmed: 31327757
Mol Cell. 2001 May;7(5):1085-94
pubmed: 11389854
Cell. 2017 Oct 5;171(2):372-384.e12
pubmed: 28942920
Life Sci. 2014 May 8;103(1):41-8
pubmed: 24631137
Nat Cell Biol. 2016 Mar;18(3):328-36
pubmed: 26900752
J Biol Chem. 2009 Sep 4;284(36):23925-34
pubmed: 19525228
J Biol Chem. 2005 Sep 30;280(39):33588-98
pubmed: 16079133
PLoS One. 2016 Jul 28;11(7):e0159092
pubmed: 27467502
Cell Metab. 2015 Nov 3;22(5):922-35
pubmed: 26437602
Cell Metab. 2016 Jun 14;23(6):1034-1047
pubmed: 27304505
J Appl Physiol (1985). 1989 Feb;66(2):695-703
pubmed: 2651385
Am J Physiol. 1993 Sep;265(3 Pt 1):E380-91
pubmed: 8214047
Am J Physiol. 1987 Nov;253(5 Pt 1):E489-95
pubmed: 3318492
Cell Metab. 2012 May 2;15(5):595-605
pubmed: 22560212