Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway.

Animals Cell Line, Tumor Female Humans Mice, Inbred C57BL Necroptosis / drug effects Phenylurea Compounds / metabolism Protein Binding Protein Kinase Inhibitors / metabolism Protein Kinases / metabolism Receptor-Interacting Protein Serine-Threonine Kinases / antagonists & inhibitors Signal Transduction / drug effects Sulfonamides / metabolism Systemic Inflammatory Response Syndrome / drug therapy

Journal

ACS chemical biology
ISSN: 1554-8937
Titre abrégé: ACS Chem Biol
Pays: United States
ID NLM: 101282906

Informations de publication

Date de publication:
16 10 2020
Historique:
pubmed: 10 9 2020
medline: 2 6 2021
entrez: 9 9 2020
Statut: ppublish

Résumé

Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound

Identifiants

DOI: 10.1021/acschembio.0c00482 PMID: 32902249
pubmed: 32902249
doi: 10.1021/acschembio.0c00482
doi:

Substances chimiques

Phenylurea Compounds 0
Protein Kinase Inhibitors 0
Sulfonamides 0
MLKL protein, human EC 2.7.-
MLKL protein, mouse EC 2.7.-
Protein Kinases EC 2.7.-
RIPK1 protein, human EC 2.7.11.1
RIPK3 protein, human EC 2.7.11.1
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1
Ripk1 protein, mouse EC 2.7.11.1
Ripk3 protein, mouse EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2702-2713

Auteurs

Catia L Pierotti (CL)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Maria C Tanzer (MC)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Annette V Jacobsen (AV)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Joanne M Hildebrand (JM)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Jean-Marc Garnier (JM)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Pooja Sharma (P)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Isabelle S Lucet (IS)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
ORCID: 0000-0002-8563-8753

Angus D Cowan (AD)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Wilhelmus J A Kersten (WJA)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

Meng-Xiao Luo (MX)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

Lung-Yu Liang (LY)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Cheree Fitzgibbon (C)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

Sarah E Garnish (SE)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Anne Hempel (A)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.

Ueli Nachbur (U)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

David C S Huang (DCS)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Peter E Czabotar (PE)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

John Silke (J)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

Mark F van Delft (MF)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

James M Murphy (JM)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
ORCID: 0000-0003-0195-3949

Guillaume Lessene (G)

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC 3052, Australia.
ORCID: 0000-0002-1193-8147

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Nécroptose › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénylurées › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Protein kinases › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Potent Inhibition of Necroptosis by...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Syndrome de réponse inflammatoire généralisée › Potent Inhibition of Necroptosis by...