Isabelle S Lucet

Affiliations

The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, 3052, Australia. lucet.i@wehi.edu.au.
Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. lucet.i@wehi.edu.au.

ORCID: http://orcid.org/0000-0002-8563-8753

Publications (21)

Eph receptor signalling: from catalytic to non-catalytic functions.

Oncogene

Avec: Lung-Yu Liang , Onisha Patel , Peter W Janes , James M Murphy , Isabelle S Lucet

Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1.

Communications biology

Avec: Onisha Patel , Michael J Roy , Ashleigh Kropp , Joshua M Hardy , Weiwen Dai , Isabelle S Lucet

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.

Nature communications

Avec: Katherine A Davies , Cheree Fitzgibbon , Samuel N Young , Sarah E Garnish , Wayland Yeung , Diane Coursier , Richard W Birkinshaw , Jarrod J Sandow , Wil I L Lehmann , Lung-Yu Liang , Isabelle S Lucet , James D Chalmers , Wayne M Patrick , Natarajan Kannan , Emma J Petrie , Peter E Czabotar , James M Murphy

The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs.

The Biochemical journal

Avec: Lung-Yu Liang , Michael Roy , Christopher R Horne , Jarrod J Sandow , Minglyanna Surudoi , Laura F Dagley , Samuel N Young , Toby Dite , Jeffrey J Babon , Peter W Janes , Onisha Patel , James M Murphy , Isabelle S Lucet

Molecular dissection of the pseudokinase ZED1 expands effector recognition to the tomato immune receptor ZAR1.

Plant physiology

Avec: Nathan Diplock , Maël Baudin , Derek Xiang , Lung-Yu Liang , Weiwen Dai , James M Murphy , Isabelle S Lucet , Jana A Hassan , Jennifer D Lewis

Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion.

Communications biology

Avec: Lung-Yu Liang , Niall D Geoghegan , Michael Mlodzianoski , Andrew Leis , Lachlan W Whitehead , Minglyanna G Surudoi , Samuel N Young , Peter Janes , Doulin Shepherd , Debnath Ghosal , Kelly L Rogers , James M Murphy , Isabelle S Lucet

DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression.

Science signaling

Avec: Shoukat Afshar-Sterle , Annalisa L E Carli , Ryan O'Keefe , Janson Tse , Stefanie Fischer , Alexander I Azimpour , David Baloyan , Lena Elias , Pathum Thilakasiri , Onisha Patel , Fleur M Ferguson , Moritz F Eissmann , Ashwini L Chand , Nathanael S Gray , Rita Busuttil , Alex Boussioutas , Isabelle S Lucet , Matthias Ernst , Michael Buchert

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein.

International journal for parasitology. Drugs and drug resistance

Avec: Brad E Sleebs , Kate E Jarman , Sonja Frolich , Wilson Wong , Julie Healer , Weiwen Dai , Isabelle S Lucet , Danny W Wilson , Alan F Cowman

Crystal structure of the putative cell-wall lipoglycan biosynthesis protein LmcA from Mycobacterium smegmatis.

Acta crystallographica. Section D, Structural biology

Avec: Onisha Patel , Rajini Brammananth , Weiwen Dai , Santosh Panjikar , Ross L Coppel , Isabelle S Lucet , Paul K Crellin

N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection.

Molecular & cellular proteomics : MCP

Avec: S Sadia Ameen , Nane Griem-Krey , Antoine Dufour , M Iqbal Hossain , Ashfaqul Hoque , Sharelle Sturgeon , Harshal Nandurkar , Dominik F Draxler , Robert L Medcalf , Mohd Aizuddin Kamaruddin , Isabelle S Lucet , Michael G Leeming , Dazhi Liu , Amardeep Dhillon , Jet Phey Lim , Faiza Basheer , Hong-Jian Zhu , Laita Bokhari , Carli L Roulston , Prasad N Paradkar , Oded Kleifeld , Andrew N Clarkson , Petrine Wellendorph , Giuseppe D Ciccotosto , Nicholas A Williamson , Ching-Seng Ang , Heung-Chin Cheng

The PEAK family of pseudokinases, their role in cell signalling and cancer.

The FEBS journal

Avec: Onisha Patel , Michael J Roy , James M Murphy , Isabelle S Lucet

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3.

Cell reports

Avec: Emma J Petrie , Jarrod J Sandow , Wil I L Lehmann , Lung-Yu Liang , Diane Coursier , Samuel N Young , Wilhelmus J A Kersten , Cheree Fitzgibbon , André L Samson , Annette V Jacobsen , Kym N Lowes , Amanda E Au , Hélène Jousset Sabroux , Najoua Lalaoui , Andrew I Webb , Guillaume Lessene , Gerard Manning , Isabelle S Lucet , James M Murphy

Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory αC helix.

Nature communications

Avec: Michael R Oliver , Christopher R Horne , Safal Shrestha , Jeremy R Keown , Lung-Yu Liang , Samuel N Young , Jarrod J Sandow , Andrew I Webb , David C Goldstone , Isabelle S Lucet , Natarajan Kannan , Peter Metcalf , James M Murphy

Production and purification of the PEAK pseudokinases for structural and functional studies.

Methods in enzymology

Avec: Onisha Patel , Minglyanna Surudoi , Weiwen Dai , Joshua M Hardy , Michael J Roy , Isabelle S Lucet

Structural mapping of PEAK pseudokinase interactions identifies 14-3-3 as a molecular switch for PEAK3 signaling.

Nature communications

Avec: Michael J Roy , Minglyanna G Surudoi , Ashleigh Kropp , Jianmei Hou , Weiwen Dai , Joshua M Hardy , Lung-Yu Liang , Thomas R Cotton , Bernhard C Lechtenberg , Toby A Dite , Xiuquan Ma , Roger J Daly , Onisha Patel , Isabelle S Lucet

Mapping and functional analysis of heterochromatin protein 1 phosphorylation in the malaria parasite Plasmodium falciparum.

Scientific reports

Avec: Hai T N Bui , Igor Niederwieser , Megan J Bird , Weiwen Dai , Nicolas M B Brancucci , Suzette Moes , Paul Jenoe , Isabelle S Lucet , Christian Doerig , Till S Voss

Potent Inhibition of Necroptosis by Simultaneously Targeting Multiple Effectors of the Pathway.

ACS chemical biology

Avec: Catia L Pierotti , Maria C Tanzer , Annette V Jacobsen , Joanne M Hildebrand , Jean-Marc Garnier , Pooja Sharma , Isabelle S Lucet , Angus D Cowan , Wilhelmus J A Kersten , Meng-Xiao Luo , Lung-Yu Liang , Cheree Fitzgibbon , Sarah E Garnish , Anne Hempel , Ueli Nachbur , David C S Huang , Peter E Czabotar , John Silke , Mark F van Delft , James M Murphy , Guillaume Lessene

Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.

Nature communications

Avec: Laura Ramos Garcia , Tencho Tenev , Richard Newman , Rachel O Haich , Gianmaria Liccardi , Sidonie Wicky John , Alessandro Annibaldi , Lu Yu , Mercedes Pardo , Samuel N Young , Cheree Fitzgibbon , Winnie Fernando , Naomi Guppy , Hyojin Kim , Lung-Yu Liang , Isabelle S Lucet , Andrew Kueh , Ioannis Roxanis , Patrycja Gazinska , Martin Sims , Tomoko Smyth , George Ward , John Bertin , Allison M Beal , Brad Geddes , Jyoti S Choudhary , James M Murphy , K Aurelia Ball , Jason W Upton , Pascal Meier

A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity.

EMBO reports

Avec: Valentin J Heim , Laura F Dagley , Che A Stafford , Fynn M Hansen , Elise Clayer , Aleksandra Bankovacki , Andrew I Webb , Isabelle S Lucet , John Silke , Ueli Nachbur

Distinct PEAK3 interactors and outputs expand the signaling potential of the PEAK pseudokinase family.

Science signaling

Avec: Jianmei Hou , Elizabeth V Nguyen , Minglyanna Surudoi , Michael J Roy , Onisha Patel , Isabelle S Lucet , Xiuquan Ma , Roger J Daly

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis.

Biomedicines

Avec: Annalisa L E Carli , Joshua M Hardy , Hanadi Hoblos , Matthias Ernst , Isabelle S Lucet , Michael Buchert

Réseau de co-auteurs

Lung-Yu Liang 10 collaborations

James M Murphy 10 collaborations

Onisha Patel 9 collaborations

Weiwen Dai 7 collaborations

Samuel N Young 6 collaborations

Michael J Roy 5 collaborations

Joshua M Hardy 4 collaborations

Cheree Fitzgibbon 4 collaborations

Jarrod J Sandow 4 collaborations

Minglyanna Surudoi 3 collaborations

Andrew I Webb 3 collaborations

Peter W Janes 2 collaborations

Ashleigh Kropp 2 collaborations

Sarah E Garnish 2 collaborations

Diane Coursier 2 collaborations

Wil I L Lehmann 2 collaborations

Natarajan Kannan 2 collaborations

Emma J Petrie 2 collaborations

Peter E Czabotar 2 collaborations

Christopher R Horne 2 collaborations

Laura F Dagley 2 collaborations

Minglyanna G Surudoi 2 collaborations

Annalisa L E Carli 2 collaborations

Matthias Ernst 2 collaborations

Michael Buchert 2 collaborations

Wilhelmus J A Kersten 2 collaborations

Annette V Jacobsen 2 collaborations

Guillaume Lessene 2 collaborations

Jianmei Hou 2 collaborations

Xiuquan Ma 2 collaborations

Roger J Daly 2 collaborations

Ueli Nachbur 2 collaborations

John Silke 2 collaborations

Katherine A Davies 1 collaboration

Wayland Yeung 1 collaboration

Richard W Birkinshaw 1 collaboration

James D Chalmers 1 collaboration

Wayne M Patrick 1 collaboration

Michael Roy 1 collaboration

Toby Dite 1 collaboration

Jeffrey J Babon 1 collaboration

Nathan Diplock 1 collaboration

Maël Baudin 1 collaboration

Derek Xiang 1 collaboration

Jana A Hassan 1 collaboration

Jennifer D Lewis 1 collaboration

Niall D Geoghegan 1 collaboration

Michael Mlodzianoski 1 collaboration

Andrew Leis 1 collaboration

Lachlan W Whitehead 1 collaboration

Peter Janes 1 collaboration

Doulin Shepherd 1 collaboration

Debnath Ghosal 1 collaboration

Kelly L Rogers 1 collaboration

Shoukat Afshar-Sterle 1 collaboration

Ryan O'Keefe 1 collaboration

Janson Tse 1 collaboration

Stefanie Fischer 1 collaboration

Alexander I Azimpour 1 collaboration

David Baloyan 1 collaboration

Lena Elias 1 collaboration

Pathum Thilakasiri 1 collaboration

Fleur M Ferguson 1 collaboration

Moritz F Eissmann 1 collaboration

Ashwini L Chand 1 collaboration

Nathanael S Gray 1 collaboration

Rita Busuttil 1 collaboration

Alex Boussioutas 1 collaboration

Brad E Sleebs 1 collaboration

Kate E Jarman 1 collaboration

Sonja Frolich 1 collaboration

Wilson Wong 1 collaboration

Julie Healer 1 collaboration

Danny W Wilson 1 collaboration

Alan F Cowman 1 collaboration

Rajini Brammananth 1 collaboration

Santosh Panjikar 1 collaboration

Ross L Coppel 1 collaboration

Paul K Crellin 1 collaboration

S Sadia Ameen 1 collaboration

Nane Griem-Krey 1 collaboration

Antoine Dufour 1 collaboration

M Iqbal Hossain 1 collaboration

Ashfaqul Hoque 1 collaboration

Sharelle Sturgeon 1 collaboration

Harshal Nandurkar 1 collaboration

Dominik F Draxler 1 collaboration

Robert L Medcalf 1 collaboration

Mohd Aizuddin Kamaruddin 1 collaboration

Michael G Leeming 1 collaboration

Dazhi Liu 1 collaboration

Amardeep Dhillon 1 collaboration

Jet Phey Lim 1 collaboration

Faiza Basheer 1 collaboration

Hong-Jian Zhu 1 collaboration

Laita Bokhari 1 collaboration

Carli L Roulston 1 collaboration

Prasad N Paradkar 1 collaboration

Oded Kleifeld 1 collaboration

Andrew N Clarkson 1 collaboration

Petrine Wellendorph 1 collaboration

Giuseppe D Ciccotosto 1 collaboration

Nicholas A Williamson 1 collaboration

Ching-Seng Ang 1 collaboration

Heung-Chin Cheng 1 collaboration

André L Samson 1 collaboration

Kym N Lowes 1 collaboration

Amanda E Au 1 collaboration

Hélène Jousset Sabroux 1 collaboration

Najoua Lalaoui 1 collaboration

Gerard Manning 1 collaboration

Michael R Oliver 1 collaboration

Safal Shrestha 1 collaboration

Jeremy R Keown 1 collaboration

David C Goldstone 1 collaboration

Peter Metcalf 1 collaboration

Thomas R Cotton 1 collaboration

Bernhard C Lechtenberg 1 collaboration

Toby A Dite 1 collaboration

Hai T N Bui 1 collaboration

Igor Niederwieser 1 collaboration

Megan J Bird 1 collaboration

Nicolas M B Brancucci 1 collaboration

Suzette Moes 1 collaboration

Paul Jenoe 1 collaboration

Christian Doerig 1 collaboration

Till S Voss 1 collaboration

Catia L Pierotti 1 collaboration

Maria C Tanzer 1 collaboration

Joanne M Hildebrand 1 collaboration

Jean-Marc Garnier 1 collaboration

Pooja Sharma 1 collaboration

Angus D Cowan 1 collaboration

Meng-Xiao Luo 1 collaboration

Anne Hempel 1 collaboration

David C S Huang 1 collaboration

Mark F van Delft 1 collaboration

Laura Ramos Garcia 1 collaboration

Tencho Tenev 1 collaboration

Richard Newman 1 collaboration

Rachel O Haich 1 collaboration

Gianmaria Liccardi 1 collaboration

Sidonie Wicky John 1 collaboration

Alessandro Annibaldi 1 collaboration

Lu Yu 1 collaboration

Mercedes Pardo 1 collaboration

Winnie Fernando 1 collaboration

Naomi Guppy 1 collaboration

Hyojin Kim 1 collaboration

Andrew Kueh 1 collaboration

Ioannis Roxanis 1 collaboration

Patrycja Gazinska 1 collaboration

Martin Sims 1 collaboration

Tomoko Smyth 1 collaboration

George Ward 1 collaboration

John Bertin 1 collaboration

Allison M Beal 1 collaboration

Brad Geddes 1 collaboration

Jyoti S Choudhary 1 collaboration

K Aurelia Ball 1 collaboration

Jason W Upton 1 collaboration

Pascal Meier 1 collaboration

Valentin J Heim 1 collaboration

Che A Stafford 1 collaboration

Fynn M Hansen 1 collaboration

Elise Clayer 1 collaboration

Aleksandra Bankovacki 1 collaboration

Elizabeth V Nguyen 1 collaboration

Hanadi Hoblos 1 collaboration