Contribution of afferent pathway to vagal nerve stimulation-induced myocardial interstitial acetylcholine release in rats.
acetylcholine
cardiac microdialysis
heart rate
rats
vagal nerve stimulation
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 11 2020
01 11 2020
Historique:
pubmed:
10
9
2020
medline:
17
12
2020
entrez:
9
9
2020
Statut:
ppublish
Résumé
Vagal nerve stimulation (VNS) has been explored as a potential therapy for chronic heart failure. The contribution of the afferent pathway to myocardial interstitial acetylcholine (ACh) release during VNS has yet to be clarified. In seven anesthetized Wistar-Kyoto rats, we implanted microdialysis probes in the left ventricular free wall and measured the myocardial interstitial ACh release during right VNS with the following combinations of stimulation frequency (F in Hz) and voltage readout (V in volts): F0V0 (no stimulation), F5V3, F20V3, F5V10, and F20V10. F5V3 did not affect the ACh level. F20V3, F5V10, and F20V10 increased the ACh level to 2.83 ± 0.47 (
Identifiants
pubmed: 32903042
doi: 10.1152/ajpregu.00080.2020
doi:
Substances chimiques
Acetylcholine
N9YNS0M02X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM