The Impact of Antibiotic-Loaded Bone Cement on Antibiotic Resistance in Periprosthetic Knee Infections.
Antibiotic laden bone cement
Antibiotic resistance
Infection
Periprosthetic knee infections
Total knee arthroplasty
Journal
Clinics in orthopedic surgery
ISSN: 2005-4408
Titre abrégé: Clin Orthop Surg
Pays: Korea (South)
ID NLM: 101505087
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
19
04
2019
accepted:
08
01
2020
entrez:
9
9
2020
pubmed:
10
9
2020
medline:
1
1
2021
Statut:
ppublish
Résumé
Antibiotic-loaded bone cement (ALBC) is commonly used in total knee arthroplasty (TKA), especially among high-risk patients. While previous studies have reported on the efficacy of ALBC in reducing the rate of periprosthetic joint infection (PJI), its impact on antibiotic resistance has not been determined. The purpose of this study was to investigate antibiotic resistance among organisms causing PJIs after TKA in which ALBC was utilized. A retrospective review from December 1998 through December 2017 identified 36 PJIs that met inclusion criteria. Patients with culture-negative infection and unknown cement type were excluded. Patient characteristics, infecting organism, and antibiotic susceptibilities were recorded. ABLC included an aminoglycoside in all cases. There was no difference in the type of PJI between the 2 groups. These results suggest that the use of ALBC does not increase the risk of antibiotic resistance or affect the pattern of infection, even as the use of ALBC continues to increase, particularly among high-risk patients.
Identifiants
pubmed: 32904007
doi: 10.4055/cios19058
pmc: PMC7449854
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bone Cements
0
Gentamicins
0
Tobramycin
VZ8RRZ51VK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
318-323Informations de copyright
Copyright © 2020 by The Korean Orthopaedic Association.
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.
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