The transcriptional repressor Bcl6 promotes pre-TCR-induced thymocyte differentiation and attenuates Notch1 activation.

Animals Blotting, Western CD4-Positive T-Lymphocytes / metabolism CD8-Positive T-Lymphocytes / metabolism Cell Differentiation / physiology Flow Cytometry Genotype Mice Receptor, Notch1 / genetics Signal Transduction / genetics Thymocytes / cytology
Bcl6 Notch Pre-TCR T-cell development Thymocyte Thymus

Journal

Development (Cambridge, England)
ISSN: 1477-9129
Titre abrégé: Development
Pays: England
ID NLM: 8701744

Informations de publication

Date de publication:
07 10 2020
Historique:
received: 28 04 2020
accepted: 06 08 2020
pubmed: 11 9 2020
medline: 10 4 2021
entrez: 10 9 2020
Statut: epublish

Résumé

Pre-T-cell receptor (TCR) signal transduction is required for developing thymocytes to differentiate from CD4

Identifiants

DOI: 10.1242/dev.192203 PMID: 32907850
pubmed: 32907850
pii: dev.192203
doi: 10.1242/dev.192203
pii:
doi:

Substances chimiques

Receptor, Notch1 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : MR/P000843/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S037764/1
Pays : United Kingdom

Informations de copyright

© 2020. Published by The Company of Biologists Ltd.

Déclaration de conflit d'intérêts

Competing interestsThe authors declare no competing or financial interests.

Auteurs

Anisha Solanki (A)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Diana C Yánez (DC)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Ching-In Lau (CI)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Jasmine Rowell (J)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
ORCID: 0000-0001-7040-8528

Alessandro Barbarulo (A)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Susan Ross (S)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Hemant Sahni (H)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.

Tessa Crompton (T)

UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK t.crompton@ucl.ac.uk.
ORCID: 0000-0002-8973-4021

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Immunotransfert › Technique de Western › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Cytophotométrie › Cytométrie en flux › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Phénomènes génétiques › Génotype › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs Notch › Récepteur Notch1 › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The transcriptional repressor Bcl6 promotes...
questionsmedicales.fr › Cellules › Thymocytes › The transcriptional repressor Bcl6 promotes...