Omega-3 fatty acid intake and decreased risk of skin cancer in organ transplant recipients.
Alpha-linolenic acid
Cohort studies
Omega-3 fatty acids
Organ transplantation
Skin neoplasms
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
09
04
2020
accepted:
28
08
2020
pubmed:
11
9
2020
medline:
24
6
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Organ transplant recipients have over 100-fold higher risk of developing skin cancer than the general population and are in need of further preventive strategies. We assessed the possible preventive effects of omega-3 polyunsaturated fatty acid (PUFA) intake from food on the two main skin cancers, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in kidney and liver transplant recipients. Adult kidney or liver transplant recipients transplanted for at least 1 year and at high risk of skin cancer were recruited from the main transplant hospital in Queensland, 2012-2014 and followed until mid-2016. We estimated their dietary total long-chain omega-3 PUFAs and α-linolenic acid intakes at baseline using a food frequency questionnaire and ranked PUFA intakes as low, medium, or high. Relative risks (RRs There were 449 transplant recipients (mean age, 55 years; 286 (64%) male). During follow-up, 149 (33%) patients developed SCC (median 2/person; range 1-40) and 134 (30%), BCC. Transplant recipients with high total long-chain omega-3 PUFA compared with low intakes showed substantially reduced SCC tumour risk (RR Among organ transplant recipients, relatively high intakes of long-chain omega-3 PUFAs and of α-linolenic acid may reduce risks of SCC and BCC, respectively.
Identifiants
pubmed: 32909136
doi: 10.1007/s00394-020-02378-y
pii: 10.1007/s00394-020-02378-y
doi:
Substances chimiques
Fatty Acids, Omega-3
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1897-1905Subventions
Organisme : National Health and Medical Research Council of Australia
ID : 552429
Organisme : National Health and Medical Research Council of Australia
ID : 1073898
Organisme : National Health and Medical Research Council of Australia
ID : APP1040947
Organisme : National Health and Medical Research Council of Australia
ID : APP1155413
Organisme : National Health and Medical Research Council of Australia
ID : APP1058522
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