Viable Hemostasis Obtained With Prothrombin Complex Concentrate in Patients Who Refuse Standard Allogeneic Blood Transfusion and Undergo Complex Cardiac Surgery: A Case Series.
Journal
A&A practice
ISSN: 2575-3126
Titre abrégé: A A Pract
Pays: United States
ID NLM: 101714112
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
entrez:
10
9
2020
pubmed:
11
9
2020
medline:
29
7
2021
Statut:
ppublish
Résumé
Human 4-factor prothrombin complex concentrate (4F-PCC) may reduce blood loss during surgery. This case series described perioperative outcomes among 9 patients who refused standard allogeneic blood transfusion, underwent complex cardiac surgery with aortic involvement, and received intraoperative 4F-PCC. Additional intraoperative cointerventions included protamine (n = 9), aminocaproic acid (n = 8), fibrinogen concentrate (n = 6), desmopressin (n = 6), factor VIIa (n = 2), and tranexamic acid (n = 1). Outcomes included postoperative death (n = 1), major postoperative bleeding (n = 1), deep vein thrombosis (n = 2), and ischemic stroke (n = 1). When standard allogeneic blood transfusion is refused, viable hemostasis can be obtained using 4F-PCC during complex cardiac surgeries with a high risk of bleeding.
Identifiants
pubmed: 32909724
doi: 10.1213/XAA.0000000000001276
pii: 02054229-202007000-00025
doi:
Substances chimiques
Blood Coagulation Factors
0
prothrombin complex concentrates
37224-63-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01276Références
Chand NK, Subramanya HB, Rao GV. Management of patients who refuse blood transfusion. Indian J Anaesth. 2014; 58:658–664
Totaro P, Carlini S, Pozzi M, et al. Minimally invasive approach for complex cardiac surgery procedures. Ann Thorac Surg. 2009; 88:462–466
Ferraris VA, Brown JR, Despotis GJ, et al. Society of Thoracic Surgeons Blood Conservation Guideline Task Force. 2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines. Ann Thorac Surg. 2011; 91:944–982
Engelman DT, Ben Ali W, Williams JB, et al. Guidelines for perioperative care in cardiac surgery: enhanced recovery after surgery society recommendations. JAMA Surg. 2019; 154:755–766
Cappabianca G, Mariscalco G, Biancari F, et al. Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery. Crit Care. 2016; 20:5
Arnékian V, Camous J, Fattal S, Rézaiguia-Delclaux S, Nottin R, Stéphan F. Use of prothrombin complex concentrate for excessive bleeding after cardiac surgery. Interact Cardiovasc Thorac Surg. 2012; 15:382–389
Dyke C, Aronson S, Dietrich W, et al. Universal definition of perioperative bleeding in adult cardiac surgery. J Thorac Cardiovasc Surg. 2014; 147:1458.e1–1463.e1
Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work GroupKDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl. 2012; 2:1–138
The Society of Thoracic Surgeons. Adult Cardiac Surgery Database.. Available at: https://www.sts.org/registries-research-center/sts-national-database/adult-cardiac-surgery-database. Accessed December 11, 2019
Harris JE, Varnado S, Herrera E, Salazar E, Colavecchia AC. Evaluation of postoperative clinical outcomes in Jehovah’s Witness patients who receive prothrombin complex concentrate during cardiac surgery. J Card Surg. 2020; 35:801–809
Kcentra (Prothrombin Complex Concentrate (Human)) [package insert]. 2018Kankakee, ILCSL Behring LLC
Goldstein LJ, Davies RR, Rizzo JA, et al. Stroke in surgery of the thoracic aorta: incidence, impact, etiology, and prevention. J Thorac Cardiovasc Surg. 2001; 122:935–945
Martens A, Beckmann E, Kaufeld T, et al. Total aortic arch repair: risk factor analysis and follow-up in 199 patients. Eur J Cardiothorac Surg. 2016; 50:940–948
Matsuura K, Ogino H, Matsuda H, et al. Prediction and incidence of atrial fibrillation after aortic arch repair. Ann Thorac Surg. 2006; 81:514–518
Schwann TA, Kistler L, Engoren MC, Habib RH. Incidence and predictors of postoperative deep vein thrombosis in cardiac surgery in the era of aggressive thromboprophylaxis. Ann Thorac Surg. 2010; 90:760–766