Di-2-ethylhexyl phthalate (DEHP) induces apoptosis of mouse HT22 hippocampal neuronal cells via oxidative stress.
Animals
Apoptosis
/ drug effects
Caspases
/ drug effects
Cell Line
Cell Survival
/ drug effects
Diethylhexyl Phthalate
/ toxicity
Dose-Response Relationship, Drug
Glutathione Peroxidase
/ antagonists & inhibitors
Hippocampus
/ drug effects
L-Lactate Dehydrogenase
/ biosynthesis
Mice
Neurons
/ drug effects
Oxidative Stress
/ drug effects
Proto-Oncogene Proteins c-bcl-2
Superoxide Dismutase
/ antagonists & inhibitors
DEHP
HT22 cells
apoptosis
oxidative stress
Journal
Toxicology and industrial health
ISSN: 1477-0393
Titre abrégé: Toxicol Ind Health
Pays: England
ID NLM: 8602702
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
pubmed:
11
9
2020
medline:
9
9
2021
entrez:
10
9
2020
Statut:
ppublish
Résumé
Di-2-ethylhexyl phthalate (DEHP) has been widely used as a plasticizer in industry and can affect memory; however, the underlying mechanism remains unclear. In the present study, mouse HT22 cells, an immortalized hippocampal neuronal cell line, was utilized as an
Identifiants
pubmed: 32909914
doi: 10.1177/0748233720947205
doi:
Substances chimiques
BCL2 protein, human
0
Proto-Oncogene Proteins c-bcl-2
0
Diethylhexyl Phthalate
C42K0PH13C
L-Lactate Dehydrogenase
EC 1.1.1.27
Glutathione Peroxidase
EC 1.11.1.9
Superoxide Dismutase
EC 1.15.1.1
Caspases
EC 3.4.22.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM