Evolution of drug delivery system from viewpoint of controlled intracellular trafficking and selective tissue targeting toward future nanomedicine.
Adjuvant
Cancer immunotherapy
Endosomal escape
Ionizable amino lipid
MEND
MITO-Porter
Mitochondrial gene therapy
Journal
Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908
Informations de publication
Date de publication:
10 11 2020
10 11 2020
Historique:
received:
29
05
2020
revised:
01
09
2020
accepted:
03
09
2020
pubmed:
12
9
2020
medline:
22
6
2021
entrez:
11
9
2020
Statut:
ppublish
Résumé
Due to the rapid changes that have occurred in the field of drug discovery and the recent developments in the early 21st century, the role of drug delivery systems (DDS) has become increasingly more important. For the past 20 years, our laboratory has been developing gene delivery systems based on lipid-based delivery systems. One of our efforts has been directed toward developing a multifunctional envelope-type nano device (MEND) by modifying the particle surface with octaarginine, which resulted in a remarkably enhanced cellular uptake and improved intracellular trafficking of plasmid DNA (pDNA). When we moved to in vivo applications, however, we were faced with the PEG-dilemma and we shifted our strategy to the incorporation of ionizable cationic lipids into our system. This resulted in some dramatic improvements over our original design and this can be attributed to the development of a new lipid library. We have also developed a mitochondrial targeting system based on a membrane fusion mechanism using a MITO-Porter, which can deliver nucleic acids/pDNA into the matrix of mitochondria. After the appearance of antibody medicines, Opdivo, an immune checkpoint inhibitor, has established cancer immunology as the 4th strategy in cancer therapy. Our DDS technologies can also be applied to this new field of cancer therapy to cure cancer by controlling our immune mechanisms. The latest studies are summarized in this review article.
Identifiants
pubmed: 32916227
pii: S0168-3659(20)30514-9
doi: 10.1016/j.jconrel.2020.09.007
pmc: PMC7477636
pii:
doi:
Substances chimiques
Lipids
0
Nucleic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-545Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Références
J Control Release. 2018 Jan 10;269:177-188
pubmed: 29146241
Drug Discov Today. 2020 Mar;25(3):552-560
pubmed: 31843577
Nature. 2014 Dec 18;516(7531):428-31
pubmed: 25337879
Trends Immunol. 2016 Mar;37(3):193-207
pubmed: 26839260
Nature. 1990 Dec 13;348(6302):651-3
pubmed: 2102678
Cell. 2010 Apr 16;141(2):210-7
pubmed: 20403315
Adv Mater. 2019 Oct;31(41):e1902251
pubmed: 31465135
PLoS One. 2017 Nov 28;12(11):e0187962
pubmed: 29182626
Nucleosides Nucleotides Nucleic Acids. 2020;39(1-3):141-155
pubmed: 31595823
Mol Ther. 2010 Jul;18(7):1357-64
pubmed: 20461061
J Pharm Sci. 2019 Aug;108(8):2668-2676
pubmed: 30959057
Oncogene. 2006 Aug 7;25(34):4647-62
pubmed: 16892079
J Control Release. 2010 May 10;143(3):311-7
pubmed: 20080139
Nihon Hinyokika Gakkai Zasshi. 1992 Feb;83(2):183-9
pubmed: 1556836
J Control Release. 2015 Oct 28;216:149-57
pubmed: 26282097
Mol Ther Nucleic Acids. 2020 Jun 5;20:687-698
pubmed: 32388194
Nanoscale. 2017 Dec 7;9(47):18690-18698
pubmed: 29165486
Nat Biotechnol. 2008 Apr;26(4):431-42
pubmed: 18376398
J Control Release. 2007 Oct 18;123(1):1-10
pubmed: 17716771
Mol Ther. 2008 Aug;16(8):1507-14
pubmed: 18560420
Mol Ther. 2011 Aug;19(8):1449-56
pubmed: 21694702
J Biochem. 1995 Oct;118(4):753-9
pubmed: 8576089
Nat Biotechnol. 2015 Aug;33(8):870-6
pubmed: 26192320
Mol Pharm. 2009 May-Jun;6(3):659-68
pubmed: 19267452
Nat Immunol. 2015 Apr;16(4):386-96
pubmed: 25665101
Int J Pharm. 2013 Jan 30;441(1-2):476-81
pubmed: 23159346
J Clin Invest. 2009 Mar;119(3):661-73
pubmed: 19229107
Handb Exp Pharmacol. 2017;240:457-472
pubmed: 27830347
Biomaterials. 2015 Jul;57:107-15
pubmed: 25913255
Mol Pharm. 2018 Jun 4;15(6):2142-2150
pubmed: 29668291
Mol Pharm. 2018 Dec 3;15(12):5762-5771
pubmed: 30380885
Biomolecules. 2020 Jan 05;10(1):
pubmed: 31948035
EMBO J. 2012 Jun 26;31(14):3038-62
pubmed: 22735187
J Control Release. 2019 Feb 10;295:140-152
pubmed: 30610950
Int Immunopharmacol. 2001 Jul;1(7):1249-59
pubmed: 11460306
J Biol Chem. 2001 Oct 19;276(42):39138-44
pubmed: 11500500
Sci Rep. 2014 Apr 23;4:4750
pubmed: 24756133
Adv Drug Deliv Rev. 2011 Mar 18;63(3):152-60
pubmed: 20840859
Nat Rev Drug Discov. 2017 Mar;16(3):203-222
pubmed: 28209991
Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1439-62
pubmed: 18655816
Gene Ther. 2001 Aug;8(15):1188-96
pubmed: 11509950
J Pharm Sci. 2016 Feb;105(2):734-740
pubmed: 26523487
Nanomedicine. 2018 Nov;14(8):2587-2597
pubmed: 30170077
Biomaterials. 2012 Feb;33(5):1589-95
pubmed: 22105068
Int J Nanomedicine. 2018 Dec 10;13:8395-8410
pubmed: 30587967
Science. 1988 Apr 29;240(4852):622-30
pubmed: 3283935
Science. 2008 Feb 1;319(5863):627-30
pubmed: 18239128
J Pharm Sci. 2016 May;105(5):1705-1713
pubmed: 27056631
Nat Immunol. 2019 May;20(5):602-612
pubmed: 30886418
Sci Rep. 2020 May 5;10(1):7511
pubmed: 32371897
Drugs. 2018 Oct;78(15):1625-1631
pubmed: 30251172
Biomaterials. 2009 May;30(15):2940-9
pubmed: 19261326
Angew Chem Int Ed Engl. 2012 Aug 20;51(34):8529-33
pubmed: 22782619
J Biol Chem. 2011 May 13;286(19):16800-6
pubmed: 21454504
Nature. 2001 May 24;411(6836):494-8
pubmed: 11373684
Nat Rev Immunol. 2009 Jan;9(1):28-38
pubmed: 19079136
J Exp Med. 2018 Dec 3;215(12):2972-2983
pubmed: 30429248
Mitochondrion. 2019 Nov;49:178-188
pubmed: 31472283
Biomaterials. 2011 Jun;32(18):4306-16
pubmed: 21429576
Curr Top Dev Biol. 2007;77:113-55
pubmed: 17222702
J Control Release. 2020 Jun 10;322:217-226
pubmed: 32145269
Biochem Biophys Res Commun. 2011 Jun 3;409(2):304-7
pubmed: 21575604
Biomaterials. 2011 Sep;32(26):6342-50
pubmed: 21658761
Science. 1999 Mar 5;283(5407):1482-8
pubmed: 10066162
Nat Biotechnol. 2013 Jul;31(7):638-46
pubmed: 23792630
Macromol Biosci. 2017 Jan;17(1):
pubmed: 27797146
J Pharm Sci. 2017 Sep;106(9):2428-2437
pubmed: 28478130
J Am Chem Soc. 2012 Apr 25;134(16):6948-51
pubmed: 22475086
J Clin Invest. 2016 Jul 1;126(7):2404-11
pubmed: 27367184
Science. 2016 Jan 22;351(6271):407-411
pubmed: 26721686
Infect Immun. 2013 Jan;81(1):311-6
pubmed: 23132493
Cancer Immunol Res. 2014 May;2(5):436-47
pubmed: 24795356
J Control Release. 2016 Dec 28;244(Pt B):194-204
pubmed: 27374187
Mol Pharm. 2015 Dec 7;12(12):4311-20
pubmed: 26567847
Mol Ther Nucleic Acids. 2012 Aug 14;1:e37
pubmed: 23344179
Nat Rev Genet. 2001 May;2(5):342-52
pubmed: 11331900
Biochim Biophys Acta. 2008 Feb;1778(2):423-32
pubmed: 18054323
J Control Release. 2014 Dec 28;196:161-7
pubmed: 25315488
Mol Ther. 2016 Apr;24(4):788-95
pubmed: 26678452
J Control Release. 2018 Aug 28;284:179-187
pubmed: 29936118
Acta Biomater. 2020 Jan 15;102:341-350
pubmed: 31733331
Nat Biotechnol. 2007 Oct;25(10):1159-64
pubmed: 17873867
Nature. 2006 May 4;441(7089):111-4
pubmed: 16565705
J Control Release. 2013 Oct 28;171(2):216-24
pubmed: 23860186
J Cell Sci. 2010 Apr 15;123(Pt 8):1183-9
pubmed: 20356929
Clin Cancer Res. 2011 Nov 15;17(22):6985-91
pubmed: 22068654
J Am Chem Soc. 2014 Dec 10;136(49):16958-61
pubmed: 25434769
J Pharm Sci. 2020 Jun;109(6):1943-1950
pubmed: 32070704
Nat Biotechnol. 2010 Feb;28(2):172-6
pubmed: 20081866
J Cell Biol. 1982 Dec;95(3):864-75
pubmed: 6296158
Annu Rev Immunol. 2005;23:975-1028
pubmed: 15771591
J Laryngol Otol. 2011 Dec;125(12):1282-5
pubmed: 21914246
J Control Release. 2017 Nov 28;266:216-225
pubmed: 28986168
J Biol Chem. 2006 Feb 10;281(6):3544-51
pubmed: 16326716
Trends Immunol. 2016 Nov;37(11):738-754
pubmed: 27623113
J Control Release. 2015 Apr 10;203:126-39
pubmed: 25701309
J Lipid Res. 1999 Jan;40(1):1-16
pubmed: 9869645
J Control Release. 2005 Oct 3;107(2):276-87
pubmed: 16054724
J Urol. 1992 Mar;147(3):596-600
pubmed: 1538436
Nature. 1998 Feb 19;391(6669):806-11
pubmed: 9486653
Mitochondrion. 2019 Nov;49:66-72
pubmed: 31326598
J Control Release. 2017 Sep 28;262:239-246
pubmed: 28774839
Nat Immunol. 2016 Sep 20;17(10):1142-9
pubmed: 27648547
Mitochondrial DNA A DNA Mapp Seq Anal. 2019 Mar;30(2):214-221
pubmed: 29764251
Biochem Biophys Res Commun. 2010 Jun 25;397(2):181-6
pubmed: 20580633
Mol Pharm. 2019 Oct 7;16(10):4372-4386
pubmed: 31437396
J Control Release. 2006 May 1;112(1):26-34
pubmed: 16529839
J Control Release. 2009 Oct 15;139(2):127-32
pubmed: 19540888
Biol Pharm Bull. 2011;34(8):1348-51
pubmed: 21804231
Diabetes. 2004 Feb;53 Suppl 1:S103-9
pubmed: 14749274
J Control Release. 2014 Jun 28;184:20-7
pubmed: 24727060
Biomaterials. 2019 Oct;218:119329
pubmed: 31306827
Sci Rep. 2016 Nov 28;6:37849
pubmed: 27892533
Nat Rev Genet. 2005 May;6(5):389-402
pubmed: 15861210
J Cell Biol. 1990 Aug;111(2):347-59
pubmed: 2199454
Gene Ther. 2007 Apr;14(8):682-9
pubmed: 17268535
Biol Pharm Bull. 2017;40(12):2183-2190
pubmed: 29199241
Immunity. 2020 Jun 16;52(6):1039-1056.e9
pubmed: 32392463
Immunity. 2013 Jul 25;39(1):1-10
pubmed: 23890059
Adv Drug Deliv Rev. 2018 Mar 15;128:84-100
pubmed: 29567396
Nat Mater. 2013 Nov;12(11):967-77
pubmed: 24150415
Cancer Res. 2005 Aug 1;65(15):6910-8
pubmed: 16061675
Mitochondrion. 2020 May;52:67-74
pubmed: 32097722
Biochem Biophys Res Commun. 2013 Nov 8;441(1):108-13
pubmed: 24134838
Gene Ther. 2008 Sep;15(17):1193-9
pubmed: 18401434
Biomaterials. 2017 Aug;136:56-66
pubmed: 28521201
Mol Ther. 2013 May;21(5):973-85
pubmed: 23439496
J Control Release. 2016 Mar 10;225:183-91
pubmed: 26820519
J Control Release. 2019 Aug 10;307:211-220
pubmed: 31170464
J Pharm Sci. 2020 Aug;109(8):2493-2500
pubmed: 32376272
J Control Release. 2014 Jan 10;173:43-50
pubmed: 24511611
J Control Release. 2015 Sep 10;213:86-95
pubmed: 26160304
Mol Pharm. 2020 Mar 2;17(3):944-953
pubmed: 31990567
Nihon Hinyokika Gakkai Zasshi. 1989 Feb;80(2):167-74
pubmed: 2747081
Cancer Res. 2017 Dec 15;77(24):6795-6811
pubmed: 29247038
Biochem Biophys Res Commun. 2005 Mar 4;328(1):57-62
pubmed: 15670750
Trends Pharmacol Sci. 2012 Jun;33(6):341-52
pubmed: 22521106
Curr Gene Ther. 2017;17(4):301-308
pubmed: 29173172
J Control Release. 2018 Mar 28;274:109-117
pubmed: 29408532
J Control Release. 2016 May 10;229:48-57
pubmed: 26995758
Sci Rep. 2019 Aug 5;9(1):11335
pubmed: 31383907
Mol Pharm. 2014 Aug 4;11(8):2787-95
pubmed: 24901376
Eur J Immunol. 2008 May;38(5):1404-13
pubmed: 18389478
Nat Rev Dis Primers. 2016 Oct 20;2:16080
pubmed: 27775730
Langmuir. 2012 Feb 21;28(7):3633-40
pubmed: 22268499
J Control Release. 2012 Nov 10;163(3):267-76
pubmed: 23000694
Chem Commun (Camb). 2019 Jun 25;55(50):7203-7206
pubmed: 31165120
Annu Rev Immunol. 2015;33:257-90
pubmed: 25581309
Ther Deliv. 2017 Nov;8(11):987-1000
pubmed: 29061103
Chem Commun (Camb). 2020 Jan 23;56(7):1145-1148
pubmed: 31895356
J Control Release. 2014 Feb 28;176:44-53
pubmed: 24389133
Sci Transl Med. 2014 Jun 11;6(240):240ps7
pubmed: 24920658
J Hepatol. 2016 Mar;64(3):547-55
pubmed: 26505121