Neural mechanisms of persistent avoidance in OCD: A novel avoidance devaluation study.
Compulsivity
Goal-directed behavior
Inhibition
Obsessive-Compulsive Disorder
fMRI
Journal
NeuroImage. Clinical
ISSN: 2213-1582
Titre abrégé: Neuroimage Clin
Pays: Netherlands
ID NLM: 101597070
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
06
2020
revised:
24
08
2020
accepted:
25
08
2020
pubmed:
12
9
2020
medline:
29
6
2021
entrez:
11
9
2020
Statut:
ppublish
Résumé
Obsessive-Compulsive Disorder (OCD) is characterized by repetitive avoidance behavior which is distressing and associated with marked impairment of everyday life. Recently, paradigms have been designed to explore the hypothesis that avoidance behavior in OCD is consistent with a formal conception of habit. Such studies have involved a devaluation paradigm, in which the value of a previously rewarded cue is altered so that avoidance is no longer necessary. We employed a rule-based avoidance task which included a devaluation, examining behavioral performance on the task and their neural correlates using functional MRI in groups of participants with OCD (n = 44) and healthy control participants (n = 46). Neuroimaging data were analyzed using a general linear model (GLM), modelling valued, devalued and control cues, as well as feedback events. First, while no overall effect of OCD was seen on devaluation performance, patients with longer illness duration showed poorer devaluation performance (χ
Identifiants
pubmed: 32916468
pii: S2213-1582(20)30241-2
doi: 10.1016/j.nicl.2020.102404
pmc: PMC7490837
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102404Subventions
Organisme : NIMH NIH HHS
ID : P50 MH106435
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Cereb Cortex. 2007 Apr;17(4):826-38
pubmed: 16699079
J Exp Psychol Gen. 2014 Dec;143(6):2316-29
pubmed: 25313953
Front Neuroinform. 2011 Aug 22;5:13
pubmed: 21897815
CNS Spectr. 2018 Oct;23(5):340-346
pubmed: 29730994
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
J Neurol Neurosurg Psychiatry. 1960 Feb;23:56-62
pubmed: 14399272
Cortex. 2017 Mar;88:143-150
pubmed: 28103527
Br J Med Psychol. 1959;32(1):50-5
pubmed: 13638508
Brain. 2015 Mar;138(Pt 3):798-811
pubmed: 25567322
Eur Neuropsychopharmacol. 2016 May;26(5):828-40
pubmed: 26774661
Clin Psychol Rev. 2011 Nov;31(7):1083-100
pubmed: 21820387
Neuroimage. 2007 Aug 1;37(1):90-101
pubmed: 17560126
Hum Brain Mapp. 2018 Oct;39(10):4065-4082
pubmed: 29923271
JAMA Psychiatry. 2020 Jan 1;77(1):77-85
pubmed: 31596434
Neuropsychologia. 2006;44(5):774-84
pubmed: 16150469
Psychol Assess. 2002 Dec;14(4):485-96
pubmed: 12501574
Biol Psychiatry. 2007 Oct 15;62(8):901-9
pubmed: 17511967
Annu Rev Psychol. 2005;56:149-78
pubmed: 15709932
JAMA Psychiatry. 2016 Aug 1;73(8):815-825
pubmed: 27276220
Biol Psychiatry. 2011 Jun 15;69(12):e113-25
pubmed: 21531388
Am J Psychiatry. 2011 Jul;168(7):718-26
pubmed: 21572165
Psychol Med. 2009 Sep;39(9):1503-18
pubmed: 19171077
J Neurosci. 2006 Mar 1;26(9):2424-33
pubmed: 16510720
Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3216-3221
pubmed: 28265059
Neuropharmacology. 1998 Apr-May;37(4-5):407-19
pubmed: 9704982
Am J Psychiatry. 2015 Mar 1;172(3):284-93
pubmed: 25526600
Neuroimage. 2013 Aug 1;76:412-27
pubmed: 23507394
Biol Psychiatry. 2014 Apr 15;75(8):631-8
pubmed: 23510580
Eur Neuropsychopharmacol. 2007 Jul;17(8):532-40
pubmed: 17275266
Neuropsychologia. 2008 Apr;46(5):1326-37
pubmed: 18242647
J Am Acad Child Adolesc Psychiatry. 2010 Sep;49(9):944-53
pubmed: 20732630
Front Psychol. 2019 Dec 11;10:2735
pubmed: 31920796
Arch Gen Psychiatry. 2006 Nov;63(11):1225-36
pubmed: 17088503
Biol Psychiatry. 2019 May 1;85(9):713-725
pubmed: 30595231
Elife. 2018 Mar 07;7:
pubmed: 29513220
J Neurosci. 2007 Apr 4;27(14):3743-52
pubmed: 17409238
Brain. 2008 Jan;131(Pt 1):155-64
pubmed: 18065438
J Clin Psychiatry. 1992 Apr;53 Suppl:4-10
pubmed: 1564054
Cereb Cortex. 2008 Jan;18(1):178-88
pubmed: 17517682
Psychol Med. 2018 Aug;48(11):1900-1908
pubmed: 29353562
J Neurosci. 2006 Apr 5;26(14):3805-12
pubmed: 16597734
Depress Anxiety. 2014 Jun;31(6):487-93
pubmed: 24616177
Trends Cogn Sci. 2014 Apr;18(4):177-85
pubmed: 24440116
J Psychiatr Res. 2013 Aug;47(8):999-1006
pubmed: 23615189