Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.
ACE2
SARS–CoV-2
epithelium
human nasal epithelial cells
infection
infectious disease
nasal epithelial cells
receptor
sphingolipid
sphingosine
spike
virus entry
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
06 11 2020
06 11 2020
Historique:
received:
16
07
2020
revised:
02
09
2020
pubmed:
13
9
2020
medline:
15
12
2020
entrez:
12
9
2020
Statut:
ppublish
Résumé
Sphingosine has been shown to prevent and eliminate bacterial infections of the respiratory tract, but it is unknown whether sphingosine can be also employed to prevent viral infections. To test this hypothesis, we analyzed whether sphingosine regulates the infection of cultured and freshly isolated
Identifiants
pubmed: 32917722
pii: S0021-9258(17)50350-6
doi: 10.1074/jbc.RA120.015249
pmc: PMC7650243
pii:
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
ACE2 protein, human
EC 3.4.17.23
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15174-15182Informations de copyright
© 2020 Edwards et al.
Déclaration de conflit d'intérêts
Conflict of interest—M. J. E. and E. G. have patented the use of sphingosine to treat viral infections.
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