Glycerophosphodiesterase 3 (GDE3) is a lysophosphatidylinositol-specific ectophospholipase C acting as an endocannabinoid signaling switch.
Amino Acid Sequence
Animals
Arachidonic Acids
/ analysis
Endocannabinoids
/ analysis
Female
Glycerides
/ analysis
HEK293 Cells
Humans
Hydrolysis
Inositol Phosphates
/ metabolism
Lysophospholipids
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Monoglycerides
/ metabolism
Phosphoric Diester Hydrolases
/ chemistry
Receptor, Cannabinoid, CB2
/ genetics
Receptors, Cannabinoid
/ metabolism
Sequence Alignment
Signal Transduction
/ drug effects
Spleen
/ metabolism
2-arachidonoylglycerol
CB1
CB1/CB2
CB2
G-protein–coupled receptor (GPCR)
GDPD2)
GPR55
endocannabinoid
glycerophosphodiesterase 3 (GDE3
lysophosphatidylinositol
lysophospholipid
monoacylglycerol
phospholipase C
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
13 11 2020
13 11 2020
Historique:
received:
17
07
2020
revised:
03
09
2020
pubmed:
13
9
2020
medline:
10
3
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
Endocannabinoid signaling plays a regulatory role in various (neuro)biological functions. 2-arachidonoylglycerol (2-AG) is the most abundant endocannabinoid, and although its canonical biosynthetic pathway involving phosphoinositide-specific phospholipase C and diacylglycerol lipase α is known, alternative pathways remain unsettled. Here, we characterize a noncanonical pathway implicating glycerophosphodiesterase 3 (GDE3, from
Identifiants
pubmed: 32917725
pii: S0021-9258(17)50403-2
doi: 10.1074/jbc.RA120.015278
pmc: PMC7667972
pii:
doi:
Substances chimiques
Arachidonic Acids
0
CNR2 protein, human
0
Endocannabinoids
0
GPR55 protein, human
0
Glycerides
0
Inositol Phosphates
0
Lysophospholipids
0
Monoglycerides
0
Receptor, Cannabinoid, CB2
0
Receptors, Cannabinoid
0
lysophosphatidylinositol
0
inositol 1-phosphate
15421-51-9
glyceryl 2-arachidonate
8D239QDW64
Phosphoric Diester Hydrolases
EC 3.1.4.-
glycerophosphodiester phosphodiesterase
EC 3.1.4.46
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15767-15781Informations de copyright
© 2020 Briand-Mésange et al.
Déclaration de conflit d'intérêts
Conflict of interest—The authors declare that they have no conflicts of interest with the contents of this article.
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