Aggressive Langerhans cell histiocytosis following T-cell acute lymphoblastic leukemia.
Langerhans cell histiocytosis
T-ALL
clonality
Journal
Pediatric blood & cancer
ISSN: 1545-5017
Titre abrégé: Pediatr Blood Cancer
Pays: United States
ID NLM: 101186624
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
02
04
2020
revised:
30
08
2020
accepted:
31
08
2020
pubmed:
13
9
2020
medline:
26
1
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
A 4-year-old female child developed cutaneous Langerhans cell histiocytosis 6 months following a diagnosis of T-cell acute lymphoblastic leukemia. Imaging revealed no evidence of systemic disease. Seven months later, the first systemic lesion was discovered on laryngoscopy. Restaging Positron Emission Tomography - Computed Tomography at that time revealed new 18-fluorodeoxyglucose-positive lesions in the left apical pleural margin, right lower peri-esophageal region, left ventricular myocardium, pancreas, upper pole of the left kidney, and inguinal and gluteal regions consistent with progressive systemic disease. Genomic testing revealed a low tumor mutational burden as well as mutations in KRAS G12A, ARID1A Q524, CDKN2A/B loss, and an alteration in NOTCH1.
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e28704Informations de copyright
© 2020 Wiley Periodicals LLC.
Références
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