Functional testing of tranexamic acid effects in patients undergoing elective orthopaedic surgery.
Hyperfibrinolysis
Orthopaedic surgery
Tranexamic acid
Viscoelastometry
Journal
Journal of thrombosis and thrombolysis
ISSN: 1573-742X
Titre abrégé: J Thromb Thrombolysis
Pays: Netherlands
ID NLM: 9502018
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
accepted:
01
09
2020
pubmed:
13
9
2020
medline:
24
12
2021
entrez:
12
9
2020
Statut:
ppublish
Résumé
Tranexamic acid (TXA) can reduce blood loss and transfusion rates in orthopaedic surgery. In this regard, a new viscoelastometric test (TPA-test, ClotPro), enables the monitoring of TXA effects. This prospective observational study evaluated and correlated TXA plasma concentrations (cTXA) following intravenous and oral administration in patients undergoing elective orthopaedic surgery with lysis variables of TPA-test. Blood samples of 42 patients were evaluated before TXA application and 2, 6, 12, 24 and 48 h afterwards. TPA-test was used to determine lysis time (LT) as well as maximum lysis (ML) and cTXA was measured using Ultra-High-Performance-Liquid-Chromatography/Mass-Spectrometry. Data are presented as median (min-max). LT
Identifiants
pubmed: 32918670
doi: 10.1007/s11239-020-02272-8
pii: 10.1007/s11239-020-02272-8
doi:
Substances chimiques
Antifibrinolytic Agents
0
Tranexamic Acid
6T84R30KC1
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
989-996Subventions
Organisme : enicor GmbH
ID : Thromboelastometric machines and reagents
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