Insights about the interaction of methotrexate loaded hydrophilic gold nanoparticles: Spectroscopic, morphological and structural characterizations.

Gold Metal Nanoparticles Methotrexate Nanoparticles Particle Size Scattering, Small Angle X-Ray Diffraction
Drug delivery Gold nanoparticles Hydrophilic nanoparticles Methotrexate Structural characterization of nanoparticles

Journal

Materials science & engineering. C, Materials for biological applications
ISSN: 1873-0191
Titre abrégé: Mater Sci Eng C Mater Biol Appl
Pays: Netherlands
ID NLM: 101484109

Informations de publication

Date de publication:
Dec 2020
Historique:
received: 03 06 2020
revised: 23 07 2020
accepted: 02 08 2020
entrez: 13 9 2020
pubmed: 14 9 2020
medline: 15 5 2021
Statut: ppublish

Résumé

Gold nanoparticles (AuNPs) are promising carriers in the field of nanomedicine and represent a very intriguing approach in drug delivery applications, due to their small size and enhanced properties. This work aims to highlight the interaction between functionalized AuNPs and the immune-system suppressant drug Methotrexate (MTX) at molecular level. Small and monodisperse (<2R

Identifiants

DOI: 10.1016/j.msec.2020.111337 PMID: 32919686
pubmed: 32919686
pii: S0928-4931(20)33255-0
doi: 10.1016/j.msec.2020.111337
pii:
doi:

Substances chimiques

Gold 7440-57-5
Methotrexate YL5FZ2Y5U1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

111337

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Sara Cerra (S)

Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address: sara.cerra@uniroma1.it.

Roberto Matassa (R)

Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Human Anatomy, Sapienza University of Rome, Via A. Borelli 50, 00161 Rome, Italy.

Ana Maria Beltrán (AM)

Departamento de Ingeniería y Ciencia de los Materiales y del Transporte, Escuela Politécnica Superior, Universidad de Sevilla, Virgen de África 7, 41011 Seville, Spain.

Giuseppe Familiari (G)

Department of Anatomical, Histological, Forensic and Orthopaedic Sciences, Section of Human Anatomy, Sapienza University of Rome, Via A. Borelli 50, 00161 Rome, Italy.

Chiara Battocchio (C)

Department of Sciences and CISDiC, Roma Tre University, via della Vasca Navale 79, 00146 Rome, Italy.

Igor Pis (I)

IOM CNR, Laboratorio TASC, S.S. 14 Km 163.5 AREA Science Park Basovizza, Trieste, Italy.

Fabio Sciubba (F)

Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.

Francesca A Scaramuzzo (FA)

Department of Basic and Applied Sciences for Engineering (SBAI), Sapienza University of Rome, Via Antonio Scarpa 14, 00161 Rome, Italy.

Alessandra Del Giudice (A)

Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.

Ilaria Fratoddi (I)

Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy. Electronic address: ilaria.fratoddi@uniroma1.it.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › Insights about the interaction of methotrexate...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Insights about the interaction of methotrexate...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Ptéridines › Aminoptérine › Méthotrexate › Insights about the interaction of methotrexate...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Insights about the interaction of methotrexate...
questionsmedicales.fr › Phénomènes chimiques › Taille de particule › Insights about the interaction of methotrexate...
questionsmedicales.fr › Phénomènes physiques › Diffusion de rayonnements › Diffusion aux petits angles › Insights about the interaction of methotrexate...
questionsmedicales.fr › Phénomènes chimiques › Diffraction des rayons X › Insights about the interaction of methotrexate...