Preparative separation of nebivolol isomers by improved throughput reverse phase tandem two column chromatography.
chiral LC
nebivolol
resolution
reverse phase chromatography
tandem chromatography
Journal
Chirality
ISSN: 1520-636X
Titre abrégé: Chirality
Pays: United States
ID NLM: 8914261
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
08
04
2020
revised:
22
07
2020
accepted:
27
08
2020
pubmed:
14
9
2020
medline:
15
7
2021
entrez:
13
9
2020
Statut:
ppublish
Résumé
Development of preparative methods for the isolation of chiral molecules has been considered challenging by conventional unit operations due to their identical physical and chemical properties. This has evolved chiral stationary phases for the separation of chiral components using chromatography technique. However, separation method using chiral adsorbents requires high pressure, are expensive, and have low productivity. Generation of bulk quantities purified nebivolols using the available high pressure chiral separation methods is impractical and operating cost-intensive. Thus, there is a need to develop economical methods using nonchiral adsorbents for the purification of nebivolols or similar active ingredients. The present work demonstrates a unique and scalable tandem two-column method for the separation of isomers of nebivolol using inexpensive reverse phase adsorbents. The first column of the scheme causes removal of charged and nonisomeric impurities whereas tandem operation of second column increases resolution of d-nebivolol and l-nebivolol. The maximization of separation due to tandem operation of second column causes enhancement of the throughput of the process. The developed preparative process produces >98% purity of both d-nebivolol and l-nebivolol with overall loading capacity of 56 g (L of adsorbent)
Substances chimiques
Nebivolol
030Y90569U
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1324-1335Informations de copyright
© 2020 Wiley Periodicals LLC.
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