Effects of intracoelomic alfaxalone-dexmedetomidine on righting reflex in common garter snakes (Thamnophis sirtalis): preliminary data.
alfaxalone
dexmedetomidine
righting reflex
snake
Journal
Veterinary anaesthesia and analgesia
ISSN: 1467-2995
Titre abrégé: Vet Anaesth Analg
Pays: United States
ID NLM: 100956422
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
27
02
2020
revised:
31
07
2020
accepted:
04
08
2020
pubmed:
15
9
2020
medline:
13
7
2021
entrez:
14
9
2020
Statut:
ppublish
Résumé
To evaluate the effect of dexmedetomidine on alfaxalone immobilization in snakes. Nonblinded, crossover study. A total of eight mature common garter snakes (Thamnophis sirtalis). Snakes were administered each of three treatments intracoelomically: alfaxalone (30 mg kg LRR occurred in eight (100%), five (63%) and three (38%) snakes in treatments A, AD0.05 and AD0.10, respectively. For all treatments, time to LRR ranged 3-20 minutes. Median (range) times to RRR were 39 (30-46), 89 (62-128) and 77 (30-185) minutes for treatments A, AD0.05 and AD0.10, respectively. In animals where righting reflex was lost, mean HR was lower in all dexmedetomidine treatments compared with treatment A. In this pilot study, alfaxalone resulted in reliable immobilization, whereas dexmedetomidine and alfaxalone combinations resulted in highly variable durations of immobilization with low HR in immobilized animals. For snakes that achieved LRR, the addition of dexmedetomidine (0.05 mg kg
Identifiants
pubmed: 32921576
pii: S1467-2987(20)30178-1
doi: 10.1016/j.vaa.2020.08.002
pii:
doi:
Substances chimiques
Anesthetics, Combined
0
Pregnanediones
0
Dexmedetomidine
67VB76HONO
alphaxalone
BD07M97B2A
Types de publication
Clinical Trial, Veterinary
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
793-796Informations de copyright
Published by Elsevier Ltd.