Effect of a DPP-4 Inhibitor on Orthodontic Tooth Movement and Associated Root Resorption.
Animals
Dipeptidyl-Peptidase IV Inhibitors
/ pharmacology
Male
Maxilla
Mice
Mice, Inbred C57BL
Models, Animal
Molar
/ drug effects
Nickel
/ pharmacology
Osteoclasts
/ drug effects
Osteogenesis
/ drug effects
RANK Ligand
/ metabolism
Root Resorption
/ drug therapy
Titanium
/ pharmacology
Tooth Movement Techniques
/ methods
Tooth Root
/ drug effects
Tumor Necrosis Factor-alpha
/ metabolism
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
06
2020
accepted:
06
08
2020
entrez:
14
9
2020
pubmed:
15
9
2020
medline:
30
4
2021
Statut:
epublish
Résumé
Dipeptidyl peptidase-4 (DPP-4) inhibitors are used as a treatment for type 2 diabetes mellitus and have also recently been applied to enhance bone quality and density, and increase the expression of bone markers. This study aimed to investigate the effect of a DPP-4 inhibitor on orthodontic tooth movement (OTM) and related root resorption in a mouse model. Mice were randomly divided into three groups: those undergoing OTM with the addition of a DPP-4 inhibitor (30 The distance of OTM and the number of osteoclasts were significantly decreased after administration of the DPP-4 inhibitor, which also significantly suppressed the number of odontoclasts and root resorption after OTM. Furthermore, the mRNA expression of tumour necrosis factor- The DPP-4 inhibitor inhibited tooth movement and associated root resorption by blocking the formation of osteoclasts and odontoclasts, respectively. It also appeared to inhibit osteoclastogenesis and odontoclastogenesis by suppressing the expression of TNF-
Identifiants
pubmed: 32923485
doi: 10.1155/2020/7189084
pmc: PMC7453249
doi:
Substances chimiques
Dipeptidyl-Peptidase IV Inhibitors
0
RANK Ligand
0
Tumor Necrosis Factor-alpha
0
titanium nickelide
12035-60-8
Nickel
7OV03QG267
Titanium
D1JT611TNE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7189084Informations de copyright
Copyright © 2020 Jiawei Qi et al.
Déclaration de conflit d'intérêts
All authors declare no conflict of interest.
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