Unmasking selective path integration deficits in Alzheimer's disease risk carriers.


Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
08 2020
Historique:
received: 07 11 2019
accepted: 15 07 2020
entrez: 14 9 2020
pubmed: 15 9 2020
medline: 13 4 2022
Statut: epublish

Résumé

Alzheimer's disease (AD) manifests with progressive memory loss and spatial disorientation. Neuropathological studies suggest early AD pathology in the entorhinal cortex (EC) of young adults at genetic risk for AD (

Identifiants

pubmed: 32923622
doi: 10.1126/sciadv.aba1394
pii: aba1394
pmc: PMC7455192
doi:

Substances chimiques

Apolipoprotein E4 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

eaba1394

Subventions

Organisme : NINDS NIH HHS
ID : U01 NS113198
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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Auteurs

Anne Bierbrauer (A)

Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.

Lukas Kunz (L)

Epilepsy Center, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106 Freiburg im Breisgau, Germany.
Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, Freiburg, Germany.
Faculty of Biology, University of Freiburg, Schänzlestraße 1, 79104 Freiburg, Germany.

Carlos A Gomes (CA)

Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.

Maike Luhmann (M)

Faculty of Psychology, Ruhr University Bochum, Bochum, Germany.

Lorena Deuker (L)

Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.

Stephan Getzmann (S)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.

Edmund Wascher (E)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.

Patrick D Gajewski (PD)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.

Jan G Hengstler (JG)

Leibniz Research Centre for Working Environment and Human Factors (IfADo), Technical University of Dortmund, Dortmund, Germany.

Marina Fernandez-Alvarez (M)

Laboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain.

Mercedes Atienza (M)

Laboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain.

Davide M Cammisuli (DM)

Department of Medicine and Surgery, Laboratory of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, University of Parma, Parma, Italy.

Francesco Bonatti (F)

Department of Medicine and Surgery, Medical Genetics, University of Parma, Parma, Italy.

Carlo Pruneti (C)

Department of Medicine and Surgery, Laboratory of Clinical Psychology, Clinical Psychophysiology and Clinical Neuropsychology, University of Parma, Parma, Italy.

Antonio Percesepe (A)

Department of Medicine and Surgery, Medical Genetics, University of Parma, Parma, Italy.

Youssef Bellaali (Y)

Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.

Bernard Hanseeuw (B)

Department of Neurology, Cliniques Universitaires Saint-Luc, Institute of Neuroscience, Université Catholique de Louvain, Brussels, Belgium.
Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Bryan A Strange (BA)

Department of Neuroimaging, Alzheimer's Disease Research Centre, Reina Sofia-CIEN Foundation, Madrid, Spain.
Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de Madrid, Madrid, Spain.

Jose L Cantero (JL)

Laboratory of Functional Neuroscience, Pablo de Olavide University, Network Center for Biomedical Research in Neurodegenerative Disease (CIBERNED), Seville, Spain.

Nikolai Axmacher (N)

Department of Neuropsychology, Institute of Cognitive Neuroscience, Faculty of Psychology, Ruhr University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.
State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research, Beijing Normal University, Xinjiekouwai Street 19, Beijing 100875, China.

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Classifications MeSH