Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways.
Cellular Microenvironment
/ drug effects
Cyclooxygenase 2
/ drug effects
Dinoprostone
/ metabolism
Fibroblasts
/ drug effects
Humans
Idiopathic Pulmonary Fibrosis
/ pathology
Imidazoles
/ pharmacology
Lung
/ drug effects
Prostaglandin-E Synthases
/ metabolism
Pyridines
/ pharmacology
Signal Transduction
/ drug effects
IPF
PGE2
PTGES
cPLA2
stiffness
Journal
American journal of respiratory cell and molecular biology
ISSN: 1535-4989
Titre abrégé: Am J Respir Cell Mol Biol
Pays: United States
ID NLM: 8917225
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
pubmed:
15
9
2020
medline:
8
1
2021
entrez:
14
9
2020
Statut:
ppublish
Résumé
Pathological changes in the biomechanical environment are implicated in the progression of idiopathic pulmonary fibrosis (IPF). Stiffened matrix augments fibroblast proliferation and differentiation and activates TGF-β1 (transforming growth factor-β1). Stiffened matrix impairs the synthesis of the antifibrogenic lipid mediator prostaglandin E
Identifiants
pubmed: 32926636
doi: 10.1165/rcmb.2020-0227OC
doi:
Substances chimiques
Imidazoles
0
Pyridines
0
Cyclooxygenase 2
EC 1.14.99.1
Prostaglandin-E Synthases
EC 5.3.99.3
Dinoprostone
K7Q1JQR04M
SB 203580
OU13V1EYWQ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
819-830Commentaires et corrections
Type : CommentIn