The Alopecia Areata Consensus of Experts (ACE) study part II: Results of an international expert opinion on diagnosis and laboratory evaluation for alopecia areata.


Journal

Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132

Informations de publication

Date de publication:
Jun 2021
Historique:
received: 29 07 2020
revised: 03 09 2020
accepted: 04 09 2020
pubmed: 15 9 2020
medline: 31 8 2021
entrez: 14 9 2020
Statut: ppublish

Résumé

We previously reported the Alopecia Areata Consensus of Experts study, which presented results of an international expert opinion on treatments for alopecia areata. To report the results of the Alopecia Areata Consensus of Experts international expert opinion on diagnosis and laboratory evaluation for alopecia areata. Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Consensus threshold was set at greater than or equal to 66%. Of 148 questions, expert consensus was achieved in 82 (55%). Round 1 consensus was achieved in 10 of 148 questions (7%). Round 2 achieved consensus in 47 of 77 questions (61%). The final face-to-face achieved consensus in 25 of 32 questions (78%). Consensus was greatest for laboratory evaluation (12 of 14 questions [86%]), followed by diagnosis (11 of 14 questions [79%]) of alopecia areata. Overall, etiopathogenesis achieved the least category consensus (31 of 68 questions [46%]). The study had low representation from Africa, South America, and Asia. There is expert consensus on aspects of epidemiology, etiopathogenesis, clinical features, diagnosis, laboratory evaluation, and prognostic indicators of alopecia areata. The study also highlights areas where future clinical research could be directed to address unresolved hypotheses in alopecia areata patient care.

Sections du résumé

BACKGROUND BACKGROUND
We previously reported the Alopecia Areata Consensus of Experts study, which presented results of an international expert opinion on treatments for alopecia areata.
OBJECTIVE OBJECTIVE
To report the results of the Alopecia Areata Consensus of Experts international expert opinion on diagnosis and laboratory evaluation for alopecia areata.
METHODS METHODS
Fifty hair experts from 5 continents were invited to participate in a 3-round Delphi process. Consensus threshold was set at greater than or equal to 66%.
RESULTS RESULTS
Of 148 questions, expert consensus was achieved in 82 (55%). Round 1 consensus was achieved in 10 of 148 questions (7%). Round 2 achieved consensus in 47 of 77 questions (61%). The final face-to-face achieved consensus in 25 of 32 questions (78%). Consensus was greatest for laboratory evaluation (12 of 14 questions [86%]), followed by diagnosis (11 of 14 questions [79%]) of alopecia areata. Overall, etiopathogenesis achieved the least category consensus (31 of 68 questions [46%]).
LIMITATIONS CONCLUSIONS
The study had low representation from Africa, South America, and Asia.
CONCLUSION CONCLUSIONS
There is expert consensus on aspects of epidemiology, etiopathogenesis, clinical features, diagnosis, laboratory evaluation, and prognostic indicators of alopecia areata. The study also highlights areas where future clinical research could be directed to address unresolved hypotheses in alopecia areata patient care.

Identifiants

pubmed: 32926985
pii: S0190-9622(20)32614-1
doi: 10.1016/j.jaad.2020.09.028
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1594-1601

Informations de copyright

Copyright © 2020 American Academy of Dermatology, Inc. All rights reserved.

Auteurs

Nekma Meah (N)

Sinclair Dermatology, East Melbourne, Victoria, Australia. Electronic address: nekma.meah@gmail.com.

Dmitri Wall (D)

Hair Restoration Blackrock, Ireland; National and International Skin Registry Solutions (NISR), Ireland.

Katherine York (K)

Netcare Greenacres Hospital, Port Elizabeth, South Africa.

Bevin Bhoyrul (B)

Sinclair Dermatology, East Melbourne, Victoria, Australia.

Laita Bokhari (L)

Sinclair Dermatology, East Melbourne, Victoria, Australia.

Daniel Asz-Sigall (D)

Dermalomas Clinic, Mexico City, Mexico.

Wilma F Bergfeld (WF)

Cleveland Clinic Main Campus, Cleveland, Ohio.

Regina C Betz (RC)

Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital, Bonn, Germany.

Ulrike Blume-Peytavi (U)

Department of Dermatology, Venerology and Allergology, Clinical Research Center for Hair and Skin Science, Charité-Universitaetsmedizin Berlin, Berlin, Germany.

Valerie Callender (V)

Callender Dermatology and Cosmetic Center, Glenn Dale, Maryland.

Vijaya Chitreddy (V)

Sinclair Dermatology, East Melbourne, Victoria, Australia.

Andrea Combalia (A)

Department of Dermatology, Hospital Clinic de Barcelona, Barcelona, Spain.

George Cotsarelis (G)

Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

Brittany Craiglow (B)

Dermatology Physicians of Connecticut, Farifield, Connecticut; Yale Department of Dermatology, New Haven, Connecticut.

Jeff Donovan (J)

Donovan Hair Clinic, Canada.

Samantha Eisman (S)

Sinclair Dermatology, East Melbourne, Victoria, Australia.

Paul Farrant (P)

Brighton and Sussex University Hospitals Trust, United Kingdom.

Jack Green (J)

Department of Dermatology, St. Vincent's Hospital, Victoria, Australia.

Ramon Grimalt (R)

Facultat de Medicina i Ciències de la Salut, Universitat Internacional de Catalunya Josep Trueta s/n 08195 Sant Cugat del Vallès, Barcelona, Spain.

Matthew Harries (M)

Centre for Dermatology Research, University of Manchester, MAHSC and NIHR Manchester, Manchester, United Kingdom; Biomedical Research Centre, Manchester, United Kingdom; The Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom.

Maria Hordinsky (M)

Department of Dermatology, University of Minnesota Medical School, Minneapolis, Minnesota.

Alan D Irvine (AD)

Clinical Medicine, Trinity College Dublin, Ireland.

Satoshi Itami (S)

Department of Dermatology, Oita University, Idaigaoka, Yufu City, Oita, Japan.

Victoria Jolliffe (V)

Centre for Cell Biology and Cutaneous Research, Blizard Institute, London, United Kingdom.

Brett King (B)

Yale School of Medicine, New Haven, Connecticut.

Won-Soo Lee (WS)

Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Amy McMichael (A)

Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Andrew Messenger (A)

Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, United Kingdom.

Paradi Mirmirani (P)

Kaiser Permanente Vallejo, Department of Dermatology, California.

Elise Olsen (E)

Duke Dermatology Clinic-Clinic 3K, Durham, North Carolina.

Seth J Orlow (SJ)

The Ronald O. Perelman Department of Dermatology at NYU Grossman School of Medicine, New York, New York.

Bianca Maria Piraccini (BM)

International Relations, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Dermatology Unit, Bologna, Italy.

Adriana Rakowska (A)

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Pascal Reygagne (P)

Centre de santé Sabouraud, Hôpital Saint Louis, Paris, France.

Janet L Roberts (JL)

Northwest Dermatology Institute Portland, Portland, Oregon.

Lidia Rudnicka (L)

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Jerry Shapiro (J)

The Ronald O. Perelman Department of Dermatology at NYU Grossman School of Medicine, New York, New York.

Pooja Sharma (P)

Sinclair Dermatology, East Melbourne, Victoria, Australia.

Antonella Tosti (A)

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine.

Annika Vogt (A)

Department of Dermatology, Venerology and Allergology, Clinical Research Center for Hair and Skin Science, Charité-Universitaetsmedizin Berlin, Berlin, Germany.

Martin Wade (M)

The London Skin and Hair Clinic, London, United Kingdom.

Leona Yip (L)

Skin Partners Specialist Dermatologists, Brisbane, Queensland, Australia.

Abraham Zlotogorski (A)

Department of Dermatology, Hadassah Medical Center, Hebrew University of Jerusalem, The Faculty of Medicine, Jerusalem, Israel.

Rodney D Sinclair (RD)

Sinclair Dermatology, East Melbourne, Victoria, Australia.

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