Plasma pharmacokinetics of (poly)phenol metabolites and catabolites after ingestion of orange juice by endurance trained men.

Citrus sinensis Eating Fruit and Vegetable Juices Humans Male Phenol Phenols
3-Hydroxy-3-(phenyl)propanoic acids Absorption Metabolites Microbial catabolites Orange juice (poly)phenols Potential bioactivity

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
20 11 2020
Historique:
received: 27 06 2020
revised: 27 08 2020
accepted: 04 09 2020
pubmed: 15 9 2020
medline: 22 6 2021
entrez: 14 9 2020
Statut: ppublish

Résumé

The health benefits of orange juice (OJ) consumption are attributed in part to the circulating flavanone phase II metabolites and their microbial-derived ring fission phenolic catabolites. The present study investigated these compounds in the bloodstream after acute intake of 500 mL of OJ. Plasma samples obtained at 0, 1, 2, 3, 4, 5, 6, 7, 8 and 24 h after OJ intake were analysed by HPLC-HR-MS. Eleven flavanone metabolites and 36 phenolic catabolites were identified and quantified in plasma. The main metabolites were hesperetin-3'-sulfate with a peak plasma concentration (C

Identifiants

DOI: 10.1016/j.freeradbiomed.2020.09.007 PMID: 32927016
pubmed: 32927016
pii: S0891-5849(20)31244-2
doi: 10.1016/j.freeradbiomed.2020.09.007
pii:
doi:

Substances chimiques

Phenols 0
Phenol 339NCG44TV

Banques de données

ClinicalTrials.gov
['NCT02627547']

Types de publication

Clinical Trial, Phase II Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

784-795

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Gema Pereira-Caro (G)

Department of Food and Health, Andalusian Institute of Agricultural and Fishery Research and Training, IFAPA, Alameda Del Obispo, 14004, Córdoba, Spain. Electronic address: mariag.pereira@juntadeandalucia.es.

Michael N Clifford (MN)

School of Bioscience and Medicine, Faculty of Health and Medical Sciences University of Surrey, Guildford, GU2 5XH, United Kingdom; Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, VIC, 3168, Australia.

Thelma Polyviou (T)

Human Nutrition, New Lister Building, University of Glasgow, Glasgow Royal Infirmary, 10-16 Alexandra Parade, Glasgow, G31 2ER, UK.

Iziar A Ludwig (IA)

Medicinal Chemistry Laboratory, Center for Applied Medicinal Research, University of Navarra, Avda. Pío XII 55, E-31008, Pamplona, Spain.

Hani Alfheeaid (H)

Department of Food Science and Human Nutrition, College of Agriculture and Veterinary Medicine, Qassim University, Saudi Arabia.

José Manuel Moreno-Rojas (JM)

Department of Food and Health, Andalusian Institute of Agricultural and Fishery Research and Training, IFAPA, Alameda Del Obispo, 14004, Córdoba, Spain.

Ada L Garcia (AL)

Human Nutrition, New Lister Building, University of Glasgow, Glasgow Royal Infirmary, 10-16 Alexandra Parade, Glasgow, G31 2ER, UK.

Dalia Malkova (D)

Human Nutrition, New Lister Building, University of Glasgow, Glasgow Royal Infirmary, 10-16 Alexandra Parade, Glasgow, G31 2ER, UK.

Alan Crozier (A)

School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, G12 8QQ, UK; United Kingdom and Department of Nutrition, University of California, Davis, CA, 95616, USA.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Rutaceae › Citrus › Citrus sinensis › Plasma pharmacokinetics of (poly)phenol...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil buccodentaire et de l'appareil digestif › Phénomènes physiologiques de l'appareil digestif › Consommation alimentaire › Plasma pharmacokinetics of (poly)phenol...
questionsmedicales.fr › Aliments et boissons › Boissons › Jus de fruits et de légumes › Plasma pharmacokinetics of (poly)phenol...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plasma pharmacokinetics of (poly)phenol...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Phénol › Plasma pharmacokinetics of (poly)phenol...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Plasma pharmacokinetics of (poly)phenol...