Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during

Animals DNA Glycosylases / antagonists & inhibitors Enzyme Inhibitors / pharmacology Inflammation / drug therapy MAP Kinase Signaling System / drug effects Macrophages / immunology Mice Pseudomonas Infections / drug therapy Pseudomonas aeruginosa / immunology

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 10 2020
Historique:
received: 31 12 2019
accepted: 17 08 2020
pubmed: 16 9 2020
medline: 30 3 2021
entrez: 15 9 2020
Statut: ppublish

Résumé

The DNA repair enzyme 8-oxoguanine DNA glycosylase 1 (OGG1), which excises 8-oxo-7,8-dihydroguanine lesions induced in DNA by reactive oxygen species, has been linked to the pathogenesis of lung diseases associated with bacterial infections. A recently developed small molecule, SU0268, has demonstrated selective inhibition of OGG1 activity; however, its role in attenuating inflammatory responses has not been tested. In this study, we report that SU0268 has a favorable effect on bacterial infection both in mouse alveolar macrophages (MH-S cells) and in C57BL/6 wild-type mice by suppressing inflammatory responses, particularly promoting type I IFN responses. SU0268 inhibited proinflammatory responses during

Identifiants

DOI: 10.4049/jimmunol.1901533 PMID: 32929043 PMC: PMC7541742
pubmed: 32929043
pii: jimmunol.1901533
doi: 10.4049/jimmunol.1901533
pmc: PMC7541742
mid: NIHMS1622294
doi:

Substances chimiques

Enzyme Inhibitors 0
DNA Glycosylases EC 3.2.2.-
Ogg1 protein, mouse EC 3.2.2.-

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

2231-2242

Subventions

Organisme : NCI NIH HHS
ID : R01 CA217809
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI097532
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI138203
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113123
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI109317
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103442
Pays : United States

Informations de copyright

Copyright © 2020 by The American Association of Immunologists, Inc.

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Auteurs

Shugang Qin (S)

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.

Ping Lin (P)

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.

Qun Wu (Q)

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.
Department of Pediatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Qinqin Pu (Q)

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.

Chuanmin Zhou (C)

Wuhan University School of Health Sciences, Wuhan, Hubei Province 430071, China.

Biao Wang (B)

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.

Pan Gao (P)

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.

Zhihan Wang (Z)

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.
West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, China; and.
ORCID: 0000-0002-3617-477X

Ashley Gao (A)

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.
ORCID: 0000-0003-4477-6831

Madison Overby (M)

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203.

Jinliang Yang (J)

State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610041, China.
ORCID: 0000-0002-6152-6394

Jianxin Jiang (J)

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, The Third Military Medical University, Chongqing 400042, China.

David L Wilson (DL)

Department of Chemistry, Stanford Cancer Institute, and Chemistry, Engineering and Medicine for Human Health Institute, Stanford University, Stanford, CA 94305.
ORCID: 0000-0002-1922-427X

Yu-Ki Tahara (YK)

Department of Chemistry, Stanford Cancer Institute, and Chemistry, Engineering and Medicine for Human Health Institute, Stanford University, Stanford, CA 94305.

Eric T Kool (ET)

Department of Chemistry, Stanford Cancer Institute, and Chemistry, Engineering and Medicine for Human Health Institute, Stanford University, Stanford, CA 94305 kool@stanford.edu xzw10484@rjh.com.cn min.wu@med.und.edu.
ORCID: 0000-0002-7310-2935

Zhenwei Xia (Z)

Department of Pediatrics, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; kool@stanford.edu xzw10484@rjh.com.cn min.wu@med.und.edu.
ORCID: 0000-0003-3811-4233

Min Wu (M)

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58203; kool@stanford.edu xzw10484@rjh.com.cn min.wu@med.und.edu.
ORCID: 0000-0003-1205-982X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › N-Glycosyl hydrolases › DNA Glycosylases › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Système de signalisation des MAP kinases › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Pseudomonas › Small-Molecule Inhibitor of 8-Oxoguanine DNA...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Small-Molecule Inhibitor of 8-Oxoguanine DNA...