Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression.
Animals
Cell Line, Tumor
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Disease Progression
Endothelial Cells
/ pathology
Hedgehog Proteins
/ genetics
Human Umbilical Vein Endothelial Cells
Humans
Lung
/ pathology
Lung Neoplasms
/ genetics
Mice, Inbred C57BL
Mice, Transgenic
Neovascularization, Pathologic
/ genetics
Oncogene Proteins
/ genetics
Oncogenes
/ genetics
Promoter Regions, Genetic
/ genetics
Proto-Oncogene Proteins p21(ras)
/ genetics
Signal Transduction
/ genetics
Transcription Factors
/ genetics
Transcription, Genetic
/ genetics
YY1 Transcription Factor
/ genetics
Kras
Lung cancer
Shh
angiogenesis
transcription
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2020
2020
Historique:
received:
27
04
2020
accepted:
02
08
2020
entrez:
15
9
2020
pubmed:
16
9
2020
medline:
29
5
2021
Statut:
epublish
Résumé
Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger transcription factor. Here, we demonstrate a new mechanism of
Identifiants
pubmed: 32929330
doi: 10.7150/thno.47491
pii: thnov10p10001
pmc: PMC7481419
doi:
Substances chimiques
Hedgehog Proteins
0
KRAS protein, human
0
Oncogene Proteins
0
SHH protein, human
0
Transcription Factors
0
YY1 Transcription Factor
0
YY1 protein, human
0
ZNF322 protein, human
0
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
10001-10015Informations de copyright
© The author(s).
Déclaration de conflit d'intérêts
Competing Interests: The authors have declared that no competing interest exists.
Références
Cancer Res. 2017 Apr 15;77(8):2134-2147
pubmed: 28202523
Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9589-94
pubmed: 21597001
Cancers (Basel). 2016 Feb 15;8(2):
pubmed: 26891329
Cancer Res. 2017 Jan 1;77(1):100-111
pubmed: 27793842
Int J Cancer. 2018 Aug 1;143(3):460-465
pubmed: 29322514
Oncogene. 2017 Oct 12;36(41):5722-5733
pubmed: 28581525
Cancer Res. 2012 May 15;72(10):2457-67
pubmed: 22589270
Nat Commun. 2019 Sep 20;10(1):4297
pubmed: 31541101
Cancer Res. 2011 Jul 15;71(14):5020-9
pubmed: 21586612
Nature. 2015 Jan 22;517(7535):489-92
pubmed: 25363767
Clin Cancer Res. 2011 Mar 15;17(6):1341-50
pubmed: 21411444
Clin Cancer Res. 2017 May 15;23(10):2377-2381
pubmed: 28073840
Blood. 2014 Apr 10;123(15):2429-37
pubmed: 24472833
Clin Epigenetics. 2019 Jun 19;11(1):92
pubmed: 31217031
Theranostics. 2020 Mar 4;10(9):4183-4200
pubmed: 32226547
Mol Cancer Ther. 2014 Feb;13(2):386-98
pubmed: 24344235
Cell Rep. 2016 Oct 4;17(2):484-500
pubmed: 27705796
Nat Commun. 2017 Feb 21;8:14294
pubmed: 28220783
Cancers (Basel). 2019 Oct 24;11(11):
pubmed: 31652979
Nature. 1983 Jun 2-8;303(5916):396-400
pubmed: 6304521
Proc Natl Acad Sci U S A. 1982 Aug;79(16):4848-52
pubmed: 6289320
Oncotarget. 2014 Dec 15;5(23):12151-65
pubmed: 25432075
Theranostics. 2020 Jun 5;10(16):7335-7350
pubmed: 32641995
Sci Rep. 2014 May 16;4:4995
pubmed: 24833309
Mol Cancer Res. 2016 Oct;14(10):1019-1029
pubmed: 27422710
Nature. 2008 Feb 21;451(7181):1008-12
pubmed: 18288196
Cancer Res. 2007 May 15;67(10):4816-26
pubmed: 17510411
Cell Chem Biol. 2017 Mar 16;24(3):252-280
pubmed: 28286127
Oncogene. 2019 Oct;38(41):6723-6736
pubmed: 31399647
Cytokine Growth Factor Rev. 2016 Oct;31:61-71
pubmed: 27578214
Theranostics. 2018 Jan 1;8(2):423-436
pubmed: 29290818
Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):3499-504
pubmed: 25739959
Front Pharmacol. 2018 Aug 22;9:958
pubmed: 30186180
Cell Commun Signal. 2018 Mar 20;16(1):11
pubmed: 29558958
Am J Pathol. 2012 Jan;180(1):2-11
pubmed: 22056910
Oncogene. 2016 May 5;35(18):2357-69
pubmed: 26279304
Cancer Lett. 2020 Apr 28;476:48-56
pubmed: 32061952
FASEB J. 2009 Jan;23(1):21-33
pubmed: 18772349
Oncogenesis. 2017 Apr 10;6(4):e313
pubmed: 28394354
Cell Death Differ. 2019 Jul;26(7):1283-1298
pubmed: 30258097
Cancer Res. 2019 Feb 1;79(3):625-638
pubmed: 30563891
Genes Dev. 1995 May 15;9(10):1188-98
pubmed: 7758944
Biochem Biophys Res Commun. 2004 Dec 24;325(4):1383-92
pubmed: 15555580