Hip Structural Analysis Reveals Impaired Hip Geometry in Girls With Type 1 Diabetes.
Absorptiometry, Photon
Adolescent
Case-Control Studies
Child
Cross-Sectional Studies
Diabetes Complications
/ diagnosis
Diabetes Mellitus, Type 1
/ complications
Female
Femur Neck
/ anatomy & histology
Hip
/ anatomy & histology
Hip Fractures
/ diagnosis
Hip Joint
/ anatomy & histology
Humans
Pelvic Bones
/ anatomy & histology
Prognosis
Risk Factors
bone accrual
osteoporosis
type 1 diabetes
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 12 2020
01 12 2020
Historique:
received:
17
06
2020
accepted:
10
09
2020
pubmed:
16
9
2020
medline:
27
2
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
Among patients with type 1 diabetes (T1D), the risk of hip fracture is up to 6-fold greater than that of the general population. However, the cause of this skeletal fragility remains poorly understood. To assess differences in hip geometry and imaging-based estimates of bone strength between youth with and without T1D using dual-energy x-ray absorptiometry (DXA)-based hip structural analysis. Cross-sectional comparison. Girls ages 10 to 16 years, including n = 62 with T1D and n = 61 controls. The groups had similar age, bone age, pubertal stage, height, lean mass, and physical activity. Bone mineral density at the femoral neck and total hip did not differ in univariate comparisons but was lower at the femoral neck in T1D after adjusting for bone age, height, and lean mass. Subjects with T1D had significantly lower cross-sectional area, cross-sectional moment of inertia, section modulus, and cortical thickness at the narrow neck, with deficits of 5.7% to 10.3%. Cross-sectional area was also lower at the intertrochanteric region in girls with T1D. Among those T1D subjects with HbA1c greater than the cohort median of 8.5%, deficits in hip geometry and strength estimates were more pronounced. DXA-based hip structural analysis revealed that girls with T1D have unfavorable geometry and lower estimates of bone strength at the hip, which may contribute to skeletal fragility and excess hip fracture risk in adulthood. Higher average glycemia may exacerbate effects of T1D on hip geometry.
Identifiants
pubmed: 32929477
pii: 5905592
doi: 10.1210/clinem/dgaa647
pmc: PMC8161549
pii:
doi:
Banques de données
ClinicalTrials.gov
['NCT02140424']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : K23 DK105350
Pays : United States
Organisme : NICHD NIH HHS
ID : K24 HD071843
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR023405
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001102
Pays : United States
Informations de copyright
The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
J Bone Miner Res. 2008 Dec;23(12):1892-904
pubmed: 18684092
Curr Osteoporos Rep. 2007 Jun;5(2):49-55
pubmed: 17521505
J Bone Miner Res. 2008 Feb;23(2):189-98
pubmed: 17922610
J Clin Densitom. 2015 Jul-Sep;18(3):331-7
pubmed: 26277850
Bone. 2019 May;122:150-155
pubmed: 30798002
J Bone Miner Res. 2016 May;31(5):1099-106
pubmed: 26599073
J Bone Miner Res. 2013 Apr;28(4):771-9
pubmed: 23044816
Osteoporos Int. 2010 Jun;21(6):919-29
pubmed: 19756830
J Pediatr. 1994 Aug;125(2):177-88
pubmed: 8040759
Diabetes Care. 2008 Sep;31(9):1729-35
pubmed: 18591404
Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7324-9
pubmed: 10377413
Bone. 2016 Jan;82:69-78
pubmed: 25722065
J Biomed Inform. 2009 Apr;42(2):377-81
pubmed: 18929686
Am J Epidemiol. 2007 Sep 1;166(5):495-505
pubmed: 17575306
Bone. 2019 Aug;125:194-199
pubmed: 31059862
Pediatr Exerc Sci. 2017 Nov 1;29(4):476-485
pubmed: 28661717
J Orthop Res. 1996 May;14(3):483-92
pubmed: 8676262
J Bone Miner Res. 2014 Jan;29(1):151-7
pubmed: 23744513
Osteoporos Int. 2009 Oct;20(10):1767-74
pubmed: 19238304
Osteoporos Int. 2012 Feb;23(2):543-51
pubmed: 21394495
J Bone Miner Res. 2002 Nov;17(11):1977-87
pubmed: 12412805
Diabetologia. 2018 Jun;61(6):1411-1423
pubmed: 29666899
J Clin Endocrinol Metab. 2020 Apr 1;105(4):
pubmed: 31761940
Arch Dis Child. 1969 Jun;44(235):291-303
pubmed: 5785179
J Cell Biochem. 2006 Oct 1;99(2):411-24
pubmed: 16619259
Diabetes. 2015 Feb;64(2):383-92
pubmed: 25157095
Osteoporos Int. 2020 Jul;31(7):1315-1322
pubmed: 32090278
J Clin Endocrinol Metab. 2015 May;100(5):2063-70
pubmed: 25751108
Osteoporos Int. 2011 May;22(5):1377-88
pubmed: 20737265
J Clin Endocrinol Metab. 2013 Apr;98(4):1742-9
pubmed: 23476076
Bone. 2019 Jun;123:260-264
pubmed: 30936041
Diabet Med. 2015 Sep;32(9):1134-42
pubmed: 26096918
J Clin Endocrinol Metab. 2020 Dec 1;105(12):
pubmed: 32929477
J Bone Miner Res. 2012 Sep;27(9):1887-95
pubmed: 22492557
Int J Endocrinol. 2014;2014:690783
pubmed: 25140176
Osteoporos Int. 2009 Oct;20(10):1633-50
pubmed: 19421703
J Bone Miner Res. 2009 Aug;24(8):1369-79
pubmed: 19292617
J Diabetes Complications. 2019 Nov;33(11):107324
pubmed: 31003922
Osteoporos Int. 2007 Dec;18(12):1583-93
pubmed: 17566814
Bone. 2005 Mar;36(3):568-76
pubmed: 15777684
Diabet Med. 2019 Aug;36(8):1013-1019
pubmed: 30848519
Osteoporos Int. 2017 Sep;28(9):2601-2610
pubmed: 28580510
Bone. 2015 Dec;81:152-160
pubmed: 26183251
Osteoporos Int. 2012 Sep;23(9):2381-6
pubmed: 22008882
Diabetes Care. 2015 Dec;38(12):e205-6
pubmed: 26604284
Sci Rep. 2019 Nov 22;9(1):17353
pubmed: 31757981
Eur J Endocrinol. 2007 Jan;156(1):123-7
pubmed: 17218735
Osteoporos Int. 2014 May;25(5):1527-33
pubmed: 24599273
J Bone Miner Res. 2000 Dec;15(12):2297-304
pubmed: 11127194
Nat Clin Pract Rheumatol. 2008 Jun;4(6):310-8
pubmed: 18431371
Growth Horm IGF Res. 2016 Jun;28:26-42
pubmed: 26432542
J Bone Miner Res. 2001 Dec;16(12):2320-9
pubmed: 11760848
J Clin Endocrinol Metab. 2013 Jul;98(7):2952-8
pubmed: 23653430
Osteoporos Int. 2014 Apr;25(4):1297-304
pubmed: 24326885