Nitric Oxide-Releasing Insert for Disinfecting the Hub Region of Tunnel Dialysis Catheters.
Anti-Bacterial Agents
/ chemical synthesis
Biofilms
/ drug effects
Catheters, Indwelling
/ adverse effects
Disinfectants
/ chemical synthesis
Disinfection
Humans
Microbial Sensitivity Tests
Nitric Oxide
/ chemical synthesis
Pseudomonas aeruginosa
/ drug effects
Renal Dialysis
/ adverse effects
Sepsis
/ drug therapy
Staphylococcus aureus
/ drug effects
S-nitrosoglutathione
antibiofilm
antimicrobial
catheters
nitric oxide
zinc oxide nanoparticles
Journal
ACS applied materials & interfaces
ISSN: 1944-8252
Titre abrégé: ACS Appl Mater Interfaces
Pays: United States
ID NLM: 101504991
Informations de publication
Date de publication:
07 Oct 2020
07 Oct 2020
Historique:
pubmed:
16
9
2020
medline:
11
3
2021
entrez:
15
9
2020
Statut:
ppublish
Résumé
The use of tunneled dialysis catheters (TDCs) for patients in need of hemodialysis treatments (HDs) causes a significant number of bloodstream infections (BSIs), with very few viable preventative/treatment methods. Use of antibiotics is relatively ineffective due to the development of multidrug-resistant bacterial strains and the inability to penetrate bacterial biofilms. Nitric oxide (NO) is an endogenous gas molecule that has broad-spectrum antimicrobial/antibiofilm activity. In this study, the potential of creating a NO-releasing insert device that is attached onto the hub region cap of TDCs and locally releases NO within the TDC hub is evaluated for its antimicrobial/antibiofilm effectiveness. The NO-releasing insert contains the natural NO donor
Identifiants
pubmed: 32931236
doi: 10.1021/acsami.0c13230
pmc: PMC8394517
mid: NIHMS1733739
doi:
Substances chimiques
Anti-Bacterial Agents
0
Disinfectants
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
44475-44484Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL128337
Pays : United States
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