Heparin-based, injectable microcarriers for controlled delivery of interleukin-13 to the brain.

Brain Cryogels Heparin Interleukin-13

Journal

Biomaterials science
ISSN: 2047-4849
Titre abrégé: Biomater Sci
Pays: England
ID NLM: 101593571

Informations de publication

Date de publication:
15 Sep 2020
Historique:
entrez: 15 9 2020
pubmed: 16 9 2020
medline: 15 5 2021
Statut: ppublish

Résumé

Interleukin-13 (IL-13) drives cells of myeloid origin towards a more anti-inflammatory phenotype, but delivery to the brain remains problematic. Herein, we show that heparin-based cryogel microcarriers load high amounts of IL-13, releasing it slowly. Intra-striatal injection of loaded microcarriers caused local up-regulation of ARG1 in myeloid cells for pro-regenerative immunomodulation in the brain.

Identifiants

DOI: 10.1039/d0bm01249a PMID: 32931543
pubmed: 32931543
doi: 10.1039/d0bm01249a
doi:

Substances chimiques

Cryogels 0
Interleukin-13 0
Heparin 9005-49-6

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

4997-5004

Subventions

Organisme : Medical Research Council
ID : G1001257
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L010305/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M02475X/1
Pays : United Kingdom

Auteurs

Lucas Schirmer (L)

Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany. newlandb@cardiff.ac.uk.

Chloé Hoornaert (C)

Laboratory of Experimental Hematology, University of Antwerp, Antwerp, Belgium.

Debbie Le Blon (D)

Laboratory of Experimental Hematology, University of Antwerp, Antwerp, Belgium and Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.

Dimitri Eigel (D)

Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany. newlandb@cardiff.ac.uk.

Catia Neto (C)

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB, Cardiff, UK.

Mark Gumbleton (M)

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB, Cardiff, UK.

Petra B Welzel (PB)

Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany. newlandb@cardiff.ac.uk.

Anne E Rosser (AE)

Brain Repair Group, School of Biosciences, Cardiff University, Cardiff, CF10 3AX Wales, UK and Neuroscience and Mental Health Institute and B.R.A.I.N unit. Cardiff University School of Medicine, Hadyn Ellis Building, Maindy Road, CF24 4HQ Cardiff, UK.

Carsten Werner (C)

Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany. newlandb@cardiff.ac.uk and Technische Universität Dresden, Center for Regenerative Therapies Dresden, Fetscherstr. 105, 01307 Dresden, Germany.
ORCID: 0000-0003-0189-3448

Peter Ponsaerts (P)

Laboratory of Experimental Hematology, University of Antwerp, Antwerp, Belgium and Vaccine and Infectious Disease Institute, University of Antwerp, Antwerp, Belgium.

Ben Newland (B)

Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Str. 6, 01069 Dresden, Germany. newlandb@cardiff.ac.uk and School of Pharmacy and Pharmaceutical Sciences, Cardiff University, CF10 3NB, Cardiff, UK.
ORCID: 0000-0002-5214-2604

Articles similaires

Multilabel SegSRGAN-A framework for parcellation and morphometry of preterm brain in MRI.

Guillaume Dollé, Gauthier Loron, Margaux Alloux et al.
1.00
Humans Magnetic Resonance Imaging Brain Infant, Newborn Infant, Premature

Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases.

Arpine Sokratian, Ye Zhou, Meltem Tatli et al.
1.00
alpha-Synuclein Humans Animals Mice Lewy Body Disease

Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior.

Jerika J Barron, Nicholas M Mroz, Sunrae E Taloma et al.
1.00
Animals Mice Immunity, Innate Interneurons Synapses

Some brain disorders are "chaperonopathies".

Manu Sharma
1.00
Humans Molecular Chaperones Brain Protein Folding Mutation

Classifications MeSH

questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Heparin-based, injectable microcarriers for...
questionsmedicales.fr › Préparations pharmaceutiques › Colloïdes › Gels › Hydrogels › Cryogels › Heparin-based, injectable microcarriers for...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Héparine › Heparin-based, injectable microcarriers for...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-13 › Heparin-based, injectable microcarriers for...