(+)-[
(+)-[18F]Flubatine [(+)-[18F]NCFHEB]
Human brain
Kinetic modeling
PET
α4β2 nicotinic acetylcholine receptors
Journal
European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
07
05
2020
accepted:
07
09
2020
pubmed:
17
9
2020
medline:
29
5
2021
entrez:
16
9
2020
Statut:
ppublish
Résumé
We present the first in-human brain PET imaging data of the new α4β2 nicotinic acetylcholine receptor (nAChR)-targeting radioligand (+)-[ We examined 11 HCs and 9 mild AD patients. All subjects underwent neuropsychological testing and [ With 270-min p.i., the unchanged parent compound amounted to 97 ± 2%. Adequate fits of the time-activity curves were obtained with the 1 tissue compartment model (1TCM). (+)-[ (+)-[
Identifiants
pubmed: 32935187
doi: 10.1007/s00259-020-05029-w
pii: 10.1007/s00259-020-05029-w
pmc: PMC8036219
doi:
Substances chimiques
Amyloid beta-Peptides
0
Aniline Compounds
0
Benzamides
0
Bridged Bicyclo Compounds, Heterocyclic
0
Ligands
0
Receptors, Nicotinic
0
fluoronorchloroepibatidine
0
nicotinic receptor alpha4beta2
0
Banques de données
EudraCT
['2012-003473-26']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
731-746Subventions
Organisme : Helmholtz validation fond
ID : HVF-0012 "NikotinPET"
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