Probing myelin content of the human brain with MRI: A review.
MRI
human brain
macromolecular content
myelin
myelin water imaging
Journal
Magnetic resonance in medicine
ISSN: 1522-2594
Titre abrégé: Magn Reson Med
Pays: United States
ID NLM: 8505245
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
09
03
2020
revised:
12
08
2020
accepted:
17
08
2020
pubmed:
17
9
2020
medline:
15
5
2021
entrez:
16
9
2020
Statut:
ppublish
Résumé
Rapid and efficient transmission of electric signals among neurons of vertebrates is ensured by myelin-insulating sheaths surrounding axons. Human cognition, sensation, and motor functions rely on the integrity of these layers, and demyelinating diseases often entail serious cognitive and physical impairments. Magnetic resonance imaging radically transformed the way these disorders are monitored, offering an irreplaceable tool to noninvasively examine the brain structure. Several advanced techniques based on MRI have been developed to provide myelin-specific contrasts and a quantitative estimation of myelin density in vivo. Here, the vast offer of acquisition strategies developed to date for this task is reviewed. Advantages and pitfalls of the different approaches are compared and discussed.
Substances chimiques
Contrast Media
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
627-652Informations de copyright
© 2020 International Society for Magnetic Resonance in Medicine.
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